Impairment of central and peripheral myelin in mitochondrial diseases

B. Kálmán, Fred D. Lublin, Hansjuerg Alder

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Clinical or sub-clinical impairment of central and peripheral myelin is of ten part of the overlapping multisystem disorders associated with a variety of mitochondrial (mt)DNA abnormalities. Suboptimal energy metabolism of the oligodendrocytes and Schwann cells carrying mitochondrial defects may cause insufficient production of myelin. Further, edema, vascular and toxic factors may directly damage myelin. The recognition that certain mtDNA point mutations are associated with inflammatory demyelination of the central nervous system suggests that additional mechanisms besides degeneration need to be considered in the development of some forms of myelin damage.

Original languageEnglish
Pages (from-to)267-278
Number of pages12
JournalMultiple Sclerosis
Volume2
Issue number6
DOIs
Publication statusPublished - 1997

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Mitochondrial Diseases
Myelin Sheath
Mitochondrial DNA
Poisons
Schwann Cells
Oligodendroglia
Demyelinating Diseases
Point Mutation
Energy Metabolism
Edema
Central Nervous System

Keywords

  • MtDNA mutations
  • Multisystem disorders
  • Myelin impairment

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Impairment of central and peripheral myelin in mitochondrial diseases. / Kálmán, B.; Lublin, Fred D.; Alder, Hansjuerg.

In: Multiple Sclerosis, Vol. 2, No. 6, 1997, p. 267-278.

Research output: Contribution to journalArticle

Kálmán, B. ; Lublin, Fred D. ; Alder, Hansjuerg. / Impairment of central and peripheral myelin in mitochondrial diseases. In: Multiple Sclerosis. 1997 ; Vol. 2, No. 6. pp. 267-278.
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