Impairment of cardiorespiratory reflexes and its association with distal somatic neuropathy in diabetic patients free from clinical symptoms of autonomic neuropathy

G. Jermendy, L. Toth, P. Voros, M. Kiraly, J. Perenyi, L. Kammerer, G. Pogatsa

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Signs of autonomic cardiac neuropathy and its association with distal somatic neuropathy were investigated in 36 type 1 and 28 type 2 diabetic patients free from clinical symptoms of autonomic neuropathy. Using bedside tests (deep-breathing, Valsalva manoeuvre and lying-to-standing) definitive cardiac autonomic neuropathy was found in 28 patients (44%), early cardiac autonomic neuropathy was observed in 19 patients (30%) while 17 patients (26%) showed no alterations. The values of motor nerve conduction velocity in peroneal nerves (41.8 ± 0.7 m/s, mean ± SEM) were significantly (p <0.01) lower in patients with definitive cardiac autonomic neuropathy than those (45.8 ± 1.1 m/s) of patients without any signs of cardiac autonomic neuropathy. These latter values were, however, significantly (p <0.001) lower than those (53.7 ± 0.7 m/s) of control subjects (n = 50). Signs of early or definitive cardiac autonomic neuropathy were recorded in 31 of 35 diabetic patients with distal somatic neuropathy assessed by measurement of motor nerve conduction velocity in peroneal nerves. It was concluded that abnormal results of noninvasive tests for autonomic neuropathy, i.e. alterations in cardiorespiratory reflexes indicating parasympathetic impairment of cardiac innervation could be often found in diabetic patients without clinical signs of autonomic neuropathy. These alterations could be frequently observed in diabetic patients with distal symmetrical somatic neuropathy.

Original languageEnglish
Pages (from-to)199-206
Number of pages8
JournalExperimental and Clinical Endocrinology
Volume95
Issue number5
Publication statusPublished - 1990

Fingerprint

Diabetic Neuropathies
Reflex
Peroneal Nerve
Neural Conduction
Valsalva Maneuver
Respiration

Keywords

  • Autonomic neuropathy
  • Cardiorespiratory reflexes
  • Deep breathing test
  • Diabetes mellitus
  • Diabetic late complications
  • Diabetic polyneuropathy
  • Heart rate variability
  • Lying-to-standing
  • Nerve conduction velocity
  • Valsalva manoeuvre

ASJC Scopus subject areas

  • Endocrinology

Cite this

Impairment of cardiorespiratory reflexes and its association with distal somatic neuropathy in diabetic patients free from clinical symptoms of autonomic neuropathy. / Jermendy, G.; Toth, L.; Voros, P.; Kiraly, M.; Perenyi, J.; Kammerer, L.; Pogatsa, G.

In: Experimental and Clinical Endocrinology, Vol. 95, No. 5, 1990, p. 199-206.

Research output: Contribution to journalArticle

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