Impaired T cell functions preceding lymphoproliferative disorders in mice neonatally tolerized to transplantation antigens.

T. Jánossy, C. Vizler, I. Ocsovszki, G. J. Tibbe, J. Pipis, H. F. Savelkoul, P. Végh, R. Benner

Research output: Contribution to journalArticle

Abstract

In A/J (H-2a) (A) mice, the neonatal i.v. injection of (B10 x A)F1 spleen cells (SC) induces partial transplantation tolerance (TT) to C57BL/10ScSn (H-2b) (B10) skin allografts, chronic host-versus-graft disease (HVGD) and lethal lymphoproliferative disorders (LPD). They produce anti-T-cell autoantibodies (ATA), and the proliferative responses of their SC to the T cell mitogen Con A are decreased. We found that, similar to ATA, the hyporeactivity of T cells developed earlier (at 1-2 weeks of age) than splenomegaly. The proportions of both CD4+ and CD8+ T cells were not reduced in the spleens of tolerized mice without manifest LPD. The supernatants (SN) of Con A-stimulated tolerized SC contained no, or only small amounts of interleukin-2 (IL-2). Thus, in the tolerized mice, ATA and T cell deficiency preceded the development of LPD. ATA and the decreased amount of the T cell growth factor IL-2 might play a role in the defective T cell activation.

Original languageEnglish
Pages (from-to)150-151
Number of pages2
JournalActa Chirurgica Hungarica
Volume36
Issue number1-4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Surgery

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