Impaired renal function is associated with mortality in kidney-transplanted patients

Adam Remport, Miklos Zsolt Molnar, Csaba Ambrus, Andras Keszei, Szilard Torok, Eszter Panna Vamos, Istvan Kiss, Jeno Jaray, Marta Novak, Laszlo Rosivall, Istvan Mucsi

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Abstract

Introduction: To date, only a few, at times conflicting, reports suggested that renal function and mortality are associated in kidney-transplanted patients. In our prevalence cohort study, we tested the hypothesis that renal function is associated with mortality in transplanted patients. Methods: Data from 985 transplanted patients were analyzed. Socio-demographic parameters, laboratory data, medical and transplant history, type of immunosuppression and estimated glomerular filtration rate were tabulated at baseline. Data on 5-year outcome were collected prospectively. Results: In multivariate Cox proportional hazard models, the estimated glomerular filtration rate measured at baseline significantly predicted mortality [hazard ratio (HR) for each 10 ml/min decrease = 1.271; 95% confidence interval (CI): 1.121-1.440] after adjustment for several covariables. Additionally, in multivariate Cox proportional hazard models, chronic kidney disease stage 4-5 (HR = 2.678; 95% CI: 1.494-4.802) significantly increased the mortality hazard compared to chronic kidney disease stage 1-2. Conclusions: Renal function is significantly and independently associated with mortality over 5 years in kidney-transplanted patients among whom mycophenolate mofetil use was very prevalent.

Original languageEnglish
Pages (from-to)799-809
Number of pages11
JournalInternational urology and nephrology
Volume42
Issue number3
DOIs
Publication statusPublished - Sep 1 2010

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Keywords

  • Chronic renal disease
  • Immunosuppression
  • Kidney transplantation
  • Mortality
  • Transplantation outcomes

ASJC Scopus subject areas

  • Nephrology
  • Urology

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