Impaired pupillary control in “schizophrenia-like” WISKET rats

Alexandra Büki, György Kalmár, G. Kékesi, Gyorgy Benedek, L. Nyúl, Gyongyi Horvath

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Patients with schizophrenia show impairments in autonomic regulation, including pupillomotor control. The aim of this study was to explore the changes of pupillary light reflex in a new substrain (WISKET) with several schizophrenia-like alterations. Male WISKET rats housed individually (for four weeks) and treated with ketamine (for 3 × 5 days) after weaning and naive group-housed Wistar rats (controls) were involved in the study. The pupillary light reflex was studied in two series after sedation (diazepam) or anesthesia (chloral hydrate). Video recordings were evaluated with custom made video analyzer software. Several significant changes were observed between the two groups: the initial and minimum pupil diameters were greater, the degree of the constriction was lower, and the flatness of the curve and the total duration of constriction were shorter in the sedated WISKET rats. No other pupillary parameters (latency, amplitude and redilation) showed significant alterations. Chloral hydrate anesthesia prolonged the constriction and redilation processes compared to the sedated animals, and diminished the differences between the groups. In conclusion, WISKET rats showed disturbances in the pupillary light reflex, suggesting a general shift of autonomic balance towards a sympathetic predominance. The results provide further evidence to support the validity of WISKET rats as a complex, chronic animal model of schizophrenia.

Original languageEnglish
Pages (from-to)34-42
Number of pages9
JournalAutonomic Neuroscience: Basic and Clinical
Volume213
DOIs
Publication statusPublished - Sep 1 2018

Fingerprint

Pupillary Reflex
Schizophrenia
Constriction
Chloral Hydrate
Light
Anesthesia
Video Recording
Ketamine
Pupil
Diazepam
Weaning
Wistar Rats
Software
Animal Models

Keywords

  • Autonomic nervous system
  • Pupillary light reflex
  • Rat model
  • Schizophrenia

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Impaired pupillary control in “schizophrenia-like” WISKET rats. / Büki, Alexandra; Kalmár, György; Kékesi, G.; Benedek, Gyorgy; Nyúl, L.; Horvath, Gyongyi.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 213, 01.09.2018, p. 34-42.

Research output: Contribution to journalArticle

Büki, Alexandra ; Kalmár, György ; Kékesi, G. ; Benedek, Gyorgy ; Nyúl, L. ; Horvath, Gyongyi. / Impaired pupillary control in “schizophrenia-like” WISKET rats. In: Autonomic Neuroscience: Basic and Clinical. 2018 ; Vol. 213. pp. 34-42.
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