Impaired nitrergic relaxation of the sphincter of Oddi of hyperlipidaemic rabbits

Zoltan Szilvassy, Istvan Nagy, Judith Szilvassy, Ildiko Jakab, Sandor Csati, Janos Lonovics

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Field stimulation relaxed the sphincter of Oddi muscle rings of the rabbit after incubation with phentolamine, oxprenolol and atropine (all 1 μM). The relaxation was blocked by N(G)-nitro-L-arginine methyl ester (30 μM) and was reversed by 3 mM L-arginine but not D-arginine. Sphincter of Oddi preparations from hypercholesterolaemic rabbits exhibited contractions under the same conditions. We conclude that nitrergic relaxation is impaired in the sphincter of Oddi from hypercholesterolaemic rabbits.

Original languageEnglish
Pages (from-to)R17-R18
JournalEuropean Journal of Pharmacology
Volume301
Issue number1-3
DOIs
Publication statusPublished - Apr 22 1996

Keywords

  • Hypercholesterolemia
  • Nitric oxide (NO)
  • Sphincter of Oddi

ASJC Scopus subject areas

  • Pharmacology

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