Impaired local deiodination of thyroxine to triiodothyronine in dogs with symmetrical truncal alopecia

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6 Citations (Scopus)

Abstract

Thyroid dysfunction causes certain dermatological alterations in dogs. Insufficient delivery of thyroid hormone to the skin may originate not only from inadequate thyroid function but also from impaired local activation of thyroxine in the target organ. Thyroid parameters and deiodination were investigated in healthy dogs (group C) and in dogs with cutaneous lesions associated with hypothyroidism (group H) or with a low-T3 syndrome (group LT). The ability of the skin to convert T4 to T3 was impaired in both groups H and LT but not in the controls. It is concluded that impaired local deiodination may contribute to skin problems in dogs.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalVeterinary Research Communications
Volume18
Issue number3
DOIs
Publication statusPublished - May 1994

Fingerprint

alopecia
Alopecia
Triiodothyronine
triiodothyronine
thyroxine
Thyroxine
skin (animal)
Dogs
Skin
Thyroid Gland
dogs
Euthyroid Sick Syndromes
thyroid function
hypothyroidism
L-thyroxine
skin lesions
thyroid hormones
Hypothyroidism
Thyroid Hormones

Keywords

  • alopecia
  • biopsy
  • dog
  • hormone
  • iodothyronine
  • serum
  • skin
  • thyroid
  • thyroxine

ASJC Scopus subject areas

  • veterinary(all)

Cite this

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title = "Impaired local deiodination of thyroxine to triiodothyronine in dogs with symmetrical truncal alopecia",
abstract = "Thyroid dysfunction causes certain dermatological alterations in dogs. Insufficient delivery of thyroid hormone to the skin may originate not only from inadequate thyroid function but also from impaired local activation of thyroxine in the target organ. Thyroid parameters and deiodination were investigated in healthy dogs (group C) and in dogs with cutaneous lesions associated with hypothyroidism (group H) or with a low-T3 syndrome (group LT). The ability of the skin to convert T4 to T3 was impaired in both groups H and LT but not in the controls. It is concluded that impaired local deiodination may contribute to skin problems in dogs.",
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author = "P. Rudas and T. Bartha and J. Toth and L. Freny{\'o}",
year = "1994",
month = "5",
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T1 - Impaired local deiodination of thyroxine to triiodothyronine in dogs with symmetrical truncal alopecia

AU - Rudas, P.

AU - Bartha, T.

AU - Toth, J.

AU - Frenyó, L.

PY - 1994/5

Y1 - 1994/5

N2 - Thyroid dysfunction causes certain dermatological alterations in dogs. Insufficient delivery of thyroid hormone to the skin may originate not only from inadequate thyroid function but also from impaired local activation of thyroxine in the target organ. Thyroid parameters and deiodination were investigated in healthy dogs (group C) and in dogs with cutaneous lesions associated with hypothyroidism (group H) or with a low-T3 syndrome (group LT). The ability of the skin to convert T4 to T3 was impaired in both groups H and LT but not in the controls. It is concluded that impaired local deiodination may contribute to skin problems in dogs.

AB - Thyroid dysfunction causes certain dermatological alterations in dogs. Insufficient delivery of thyroid hormone to the skin may originate not only from inadequate thyroid function but also from impaired local activation of thyroxine in the target organ. Thyroid parameters and deiodination were investigated in healthy dogs (group C) and in dogs with cutaneous lesions associated with hypothyroidism (group H) or with a low-T3 syndrome (group LT). The ability of the skin to convert T4 to T3 was impaired in both groups H and LT but not in the controls. It is concluded that impaired local deiodination may contribute to skin problems in dogs.

KW - alopecia

KW - biopsy

KW - dog

KW - hormone

KW - iodothyronine

KW - serum

KW - skin

KW - thyroid

KW - thyroxine

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U2 - 10.1007/BF01839266

DO - 10.1007/BF01839266

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