Impaired local deiodination of thyroxine to triiodothyronine in dogs with symmetrical truncal alopecia

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Thyroid dysfunction causes certain dermatological alterations in dogs. Insufficient delivery of thyroid hormone to the skin may originate not only from inadequate thyroid function but also from impaired local activation of thyroxine in the target organ. Thyroid parameters and deiodination were investigated in healthy dogs (group C) and in dogs with cutaneous lesions associated with hypothyroidism (group H) or with a low-T3 syndrome (group LT). The ability of the skin to convert T4 to T3 was impaired in both groups H and LT but not in the controls. It is concluded that impaired local deiodination may contribute to skin problems in dogs.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalVeterinary research communications
Volume18
Issue number3
DOIs
Publication statusPublished - May 1 1994

    Fingerprint

Keywords

  • alopecia
  • biopsy
  • dog
  • hormone
  • iodothyronine
  • serum
  • skin
  • thyroid
  • thyroxine

ASJC Scopus subject areas

  • veterinary(all)

Cite this