Impaired learning and abnormal open-field behaviours of rats after early postnatal anoxia and the beneficial effect of the calcium antagonist nimodipine

C. Nyakas, E. Markel, T. Schuurman, P. G M Luiten

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Perinatal anoxia/hypoxia is considered a serious risk factor for normal brain developent. Anoxia induced by repeated asphyxia at 2 and 4 days after birth resulted in a transient hyperactivity in the small open-field, and a behavioural depression in adult open-field activity of male Wistar rats. The same treatment impaired adult learning behaviour in pole-jumping conditioned avoidance and appetitively motivated hole-board test situations. The calcium entry blocker nimodipine (in doses of 3 and 10 mg/kg) prevented the anoxia-induced changes in orientation motility in the open-field tests and almost fully antagonized the learning deficit in the hole-board test. The behavioural deficit seen during acquisition of the pole-jumping conditioned avoidance response was ameliorated to a lesser degree. The results indicate that the maintenance of calcium homeostasis during the early postnatal phase of brain development is crucial to prevent anoxia-induced behavioural abnormalities.

Original languageEnglish
Pages (from-to)168-174
Number of pages7
JournalEuropean Journal of Neuroscience
Volume3
Issue number2
Publication statusPublished - 1991

Fingerprint

Nimodipine
Learning
Calcium
Asphyxia
Brain
Wistar Rats
Homeostasis
Maintenance
Hypoxia
Parturition
Depression

Keywords

  • Avoidance and spatial learning
  • Neonatal asphyxia
  • Neuroprotection
  • Orientation motility

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Impaired learning and abnormal open-field behaviours of rats after early postnatal anoxia and the beneficial effect of the calcium antagonist nimodipine. / Nyakas, C.; Markel, E.; Schuurman, T.; Luiten, P. G M.

In: European Journal of Neuroscience, Vol. 3, No. 2, 1991, p. 168-174.

Research output: Contribution to journalArticle

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