Impaired corticosteroid production by isolated adrenocortical cells of hypercholesterolemic rabbits

I. E. Tóth, D. Szabó, K. S.Z. Szalay, A. Hesz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Changes in the structure and function of rabbit adrenocortical cells were studied eight weeks after cessation of a cholesterol-enriched diet. The plasma cholesterol level of the treated animals was still modestly elevated. All three zones of the adrenal cortex contained a slightly increased number of intracellular lipid droplets, and greater number of lipid-laden macrophages were located in the inner layers, as revealed by light and electron microscopy. The basal and ACTH-stimulated hormone production by the isolated adrenocortical cells were significantly inhibited compared with those of the controls. A possible causal relationship between the inhibited adrenocortical hormone production and the increased number of macrophages is discussed.

Original languageEnglish
Pages (from-to)93-105
Number of pages13
JournalEndocrine Research
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 1 1990

ASJC Scopus subject areas

  • Endocrinology

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