Impaired coronary flow velocity reserve and aortic distensibility in patients with untreated hypercholesterolemia - An echocardiographic study

Attila Nemes, T. Forster, M. Csanády

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17 Citations (Scopus)

Abstract

Introduction: Hypercholesterolemia is a primary risk factor for the development of atherosclerosis and leading to severe stages of coronary artery disease (CAD) and aortic atherosclerosis (AA). The objective of this investigation was to measure elastic modulus [(E (p), in 103 mmHg] and Young's circumferential static elastic modulus [(E(s), in 103 mmHg] as aortic distensibility indices and coronary flow velocity reserve (CFR) in untreated hypercholesterolemic (HC) patients in the course of the same stress transesophageal echocardiography (TEE) and to compare their results to normochole-sterolemic (NC) subjects. Patients and methods: The following patient populations were compared: 17 NC subjects with negative coronary angiograms, 18 patients with untreated hypercholesterolemia with a negative coronary angiogram and 23 HC patients with significant left anterior descending coronary artery (LAD) disease. All patients underwent coronary angiography, transthoracic and stress TEE examinations. Results: CFR was significantly reduced in patients of both groups with hypercholesterolemia as compared to NC subjects (1.99±0.76 and 1.79±0.32 vs. 2.58±0.63, P <0.05, respectively). E(p) was significantly increased in HC patients with negative coronary angiograms as compared to NC subjects (0.39±0.18 vs. 0.67±0.19, P <0.05), while further increase was found in HC patients with LAD disease (0.67±0.19 vs. 1.09±0.52, P <0.05). E(s) behaved similarly (4.06±2.73 vs. 7.60±3.70 vs. 11.38±6.91, P <0.05, respectively). Conclusion: In conclusion it may be stated that CFR and aortic distensibility indices can be evaluated simultaneously by stress TEE in HC patients. CFR and aortic distensibility were impaired in HC patients as compared to NC subjects.

Original languageEnglish
Pages (from-to)15-23
Number of pages9
JournalInternational Journal of Cardiovascular Imaging
Volume23
Issue number1
DOIs
Publication statusPublished - Feb 2007

Fingerprint

Hypercholesterolemia
Stress Echocardiography
Transesophageal Echocardiography
Angiography
Elastic Modulus
Coronary Artery Disease
Atherosclerosis
Coronary Angiography

Keywords

  • Aortic distensibility
  • Coronary flow reserve
  • Hypercholesterolemia
  • Transesophageal echocardiography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine
  • Radiological and Ultrasound Technology

Cite this

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title = "Impaired coronary flow velocity reserve and aortic distensibility in patients with untreated hypercholesterolemia - An echocardiographic study",
abstract = "Introduction: Hypercholesterolemia is a primary risk factor for the development of atherosclerosis and leading to severe stages of coronary artery disease (CAD) and aortic atherosclerosis (AA). The objective of this investigation was to measure elastic modulus [(E (p), in 103 mmHg] and Young's circumferential static elastic modulus [(E(s), in 103 mmHg] as aortic distensibility indices and coronary flow velocity reserve (CFR) in untreated hypercholesterolemic (HC) patients in the course of the same stress transesophageal echocardiography (TEE) and to compare their results to normochole-sterolemic (NC) subjects. Patients and methods: The following patient populations were compared: 17 NC subjects with negative coronary angiograms, 18 patients with untreated hypercholesterolemia with a negative coronary angiogram and 23 HC patients with significant left anterior descending coronary artery (LAD) disease. All patients underwent coronary angiography, transthoracic and stress TEE examinations. Results: CFR was significantly reduced in patients of both groups with hypercholesterolemia as compared to NC subjects (1.99±0.76 and 1.79±0.32 vs. 2.58±0.63, P <0.05, respectively). E(p) was significantly increased in HC patients with negative coronary angiograms as compared to NC subjects (0.39±0.18 vs. 0.67±0.19, P <0.05), while further increase was found in HC patients with LAD disease (0.67±0.19 vs. 1.09±0.52, P <0.05). E(s) behaved similarly (4.06±2.73 vs. 7.60±3.70 vs. 11.38±6.91, P <0.05, respectively). Conclusion: In conclusion it may be stated that CFR and aortic distensibility indices can be evaluated simultaneously by stress TEE in HC patients. CFR and aortic distensibility were impaired in HC patients as compared to NC subjects.",
keywords = "Aortic distensibility, Coronary flow reserve, Hypercholesterolemia, Transesophageal echocardiography",
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T1 - Impaired coronary flow velocity reserve and aortic distensibility in patients with untreated hypercholesterolemia - An echocardiographic study

AU - Nemes, Attila

AU - Forster, T.

AU - Csanády, M.

PY - 2007/2

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N2 - Introduction: Hypercholesterolemia is a primary risk factor for the development of atherosclerosis and leading to severe stages of coronary artery disease (CAD) and aortic atherosclerosis (AA). The objective of this investigation was to measure elastic modulus [(E (p), in 103 mmHg] and Young's circumferential static elastic modulus [(E(s), in 103 mmHg] as aortic distensibility indices and coronary flow velocity reserve (CFR) in untreated hypercholesterolemic (HC) patients in the course of the same stress transesophageal echocardiography (TEE) and to compare their results to normochole-sterolemic (NC) subjects. Patients and methods: The following patient populations were compared: 17 NC subjects with negative coronary angiograms, 18 patients with untreated hypercholesterolemia with a negative coronary angiogram and 23 HC patients with significant left anterior descending coronary artery (LAD) disease. All patients underwent coronary angiography, transthoracic and stress TEE examinations. Results: CFR was significantly reduced in patients of both groups with hypercholesterolemia as compared to NC subjects (1.99±0.76 and 1.79±0.32 vs. 2.58±0.63, P <0.05, respectively). E(p) was significantly increased in HC patients with negative coronary angiograms as compared to NC subjects (0.39±0.18 vs. 0.67±0.19, P <0.05), while further increase was found in HC patients with LAD disease (0.67±0.19 vs. 1.09±0.52, P <0.05). E(s) behaved similarly (4.06±2.73 vs. 7.60±3.70 vs. 11.38±6.91, P <0.05, respectively). Conclusion: In conclusion it may be stated that CFR and aortic distensibility indices can be evaluated simultaneously by stress TEE in HC patients. CFR and aortic distensibility were impaired in HC patients as compared to NC subjects.

AB - Introduction: Hypercholesterolemia is a primary risk factor for the development of atherosclerosis and leading to severe stages of coronary artery disease (CAD) and aortic atherosclerosis (AA). The objective of this investigation was to measure elastic modulus [(E (p), in 103 mmHg] and Young's circumferential static elastic modulus [(E(s), in 103 mmHg] as aortic distensibility indices and coronary flow velocity reserve (CFR) in untreated hypercholesterolemic (HC) patients in the course of the same stress transesophageal echocardiography (TEE) and to compare their results to normochole-sterolemic (NC) subjects. Patients and methods: The following patient populations were compared: 17 NC subjects with negative coronary angiograms, 18 patients with untreated hypercholesterolemia with a negative coronary angiogram and 23 HC patients with significant left anterior descending coronary artery (LAD) disease. All patients underwent coronary angiography, transthoracic and stress TEE examinations. Results: CFR was significantly reduced in patients of both groups with hypercholesterolemia as compared to NC subjects (1.99±0.76 and 1.79±0.32 vs. 2.58±0.63, P <0.05, respectively). E(p) was significantly increased in HC patients with negative coronary angiograms as compared to NC subjects (0.39±0.18 vs. 0.67±0.19, P <0.05), while further increase was found in HC patients with LAD disease (0.67±0.19 vs. 1.09±0.52, P <0.05). E(s) behaved similarly (4.06±2.73 vs. 7.60±3.70 vs. 11.38±6.91, P <0.05, respectively). Conclusion: In conclusion it may be stated that CFR and aortic distensibility indices can be evaluated simultaneously by stress TEE in HC patients. CFR and aortic distensibility were impaired in HC patients as compared to NC subjects.

KW - Aortic distensibility

KW - Coronary flow reserve

KW - Hypercholesterolemia

KW - Transesophageal echocardiography

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