Impaired cerebral vasoreactivity in white coat hypertensive adolescents

D. Páll, S. Lengyel, É Komonyi, C. Molnár, G. Paragh, B. Fülesdi, É Katona

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background and purpose: Although its incidence is not high, adolescent hypertension may predict hypertension and increased cardiovascular risk in adulthood. Therefore, the aim of the present study was to assess whether cerebrovascular reactivity is altered in adolescent white coat and sustained hypertensive patients compared to healthy teenagers. Methods: Fifty-nine normotensive, 47 white coat hypertensive (WCH), and 73 sustained hypertensive (SH) adolescents were studied. WCH and SH were differentiated by ambulatory blood pressure monitoring. Cerebrovascular reactivity was assessed by transcranial Doppler breath-holding test and was expressed in percent (%) change to the resting cerebral blood flow velocity value. Results: The percent increase in middle cerebral artery mean blood flow velocity after 30s of breath holding was lower in both WCH (5.3±3.1%) and SH (9.5±2.6%) groups indicating lower vasodilatory reactivity compared to healthy adolescents (12.1±2.2%). Additionally, serum nitric oxide (NOx) concentrations were lower in both WCH (30.6±11μM) and SH (30.7±22.4μM) groups compared to controls (38.8±7.6μM). Conclusions: Both white coat and sustained hypertension result in decreased vasodilatory reaction to CO2 in adolescents, suggesting involvement of the cerebral arterioles. The present study underlines the importance of early recognition and proper treatment of adolescent hypertension in order to prevent long-term cardiovascular complications.

Original languageEnglish
Pages (from-to)584-589
Number of pages6
JournalEuropean Journal of Neurology
Volume18
Issue number4
DOIs
Publication statusPublished - Apr 2011

Fingerprint

Breath Holding
Blood Flow Velocity
Hypertension
Cerebrovascular Circulation
White Coat Hypertension
Ambulatory Blood Pressure Monitoring
Breath Tests
Middle Cerebral Artery
Arterioles
Nitric Oxide
Incidence
Serum
Therapeutics

Keywords

  • Adolescent hypertension
  • Cerebral vasoreactivity
  • Transcranial Doppler sonography
  • White coat and sustained hypertension

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Impaired cerebral vasoreactivity in white coat hypertensive adolescents. / Páll, D.; Lengyel, S.; Komonyi, É; Molnár, C.; Paragh, G.; Fülesdi, B.; Katona, É.

In: European Journal of Neurology, Vol. 18, No. 4, 04.2011, p. 584-589.

Research output: Contribution to journalArticle

Páll, D. ; Lengyel, S. ; Komonyi, É ; Molnár, C. ; Paragh, G. ; Fülesdi, B. ; Katona, É. / Impaired cerebral vasoreactivity in white coat hypertensive adolescents. In: European Journal of Neurology. 2011 ; Vol. 18, No. 4. pp. 584-589.
@article{91c229f7b2fa448cba290871634930a3,
title = "Impaired cerebral vasoreactivity in white coat hypertensive adolescents",
abstract = "Background and purpose: Although its incidence is not high, adolescent hypertension may predict hypertension and increased cardiovascular risk in adulthood. Therefore, the aim of the present study was to assess whether cerebrovascular reactivity is altered in adolescent white coat and sustained hypertensive patients compared to healthy teenagers. Methods: Fifty-nine normotensive, 47 white coat hypertensive (WCH), and 73 sustained hypertensive (SH) adolescents were studied. WCH and SH were differentiated by ambulatory blood pressure monitoring. Cerebrovascular reactivity was assessed by transcranial Doppler breath-holding test and was expressed in percent ({\%}) change to the resting cerebral blood flow velocity value. Results: The percent increase in middle cerebral artery mean blood flow velocity after 30s of breath holding was lower in both WCH (5.3±3.1{\%}) and SH (9.5±2.6{\%}) groups indicating lower vasodilatory reactivity compared to healthy adolescents (12.1±2.2{\%}). Additionally, serum nitric oxide (NOx) concentrations were lower in both WCH (30.6±11μM) and SH (30.7±22.4μM) groups compared to controls (38.8±7.6μM). Conclusions: Both white coat and sustained hypertension result in decreased vasodilatory reaction to CO2 in adolescents, suggesting involvement of the cerebral arterioles. The present study underlines the importance of early recognition and proper treatment of adolescent hypertension in order to prevent long-term cardiovascular complications.",
keywords = "Adolescent hypertension, Cerebral vasoreactivity, Transcranial Doppler sonography, White coat and sustained hypertension",
author = "D. P{\'a}ll and S. Lengyel and {\'E} Komonyi and C. Moln{\'a}r and G. Paragh and B. F{\"u}lesdi and {\'E} Katona",
year = "2011",
month = "4",
doi = "10.1111/j.1468-1331.2010.03209.x",
language = "English",
volume = "18",
pages = "584--589",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Impaired cerebral vasoreactivity in white coat hypertensive adolescents

AU - Páll, D.

AU - Lengyel, S.

AU - Komonyi, É

AU - Molnár, C.

AU - Paragh, G.

AU - Fülesdi, B.

AU - Katona, É

PY - 2011/4

Y1 - 2011/4

N2 - Background and purpose: Although its incidence is not high, adolescent hypertension may predict hypertension and increased cardiovascular risk in adulthood. Therefore, the aim of the present study was to assess whether cerebrovascular reactivity is altered in adolescent white coat and sustained hypertensive patients compared to healthy teenagers. Methods: Fifty-nine normotensive, 47 white coat hypertensive (WCH), and 73 sustained hypertensive (SH) adolescents were studied. WCH and SH were differentiated by ambulatory blood pressure monitoring. Cerebrovascular reactivity was assessed by transcranial Doppler breath-holding test and was expressed in percent (%) change to the resting cerebral blood flow velocity value. Results: The percent increase in middle cerebral artery mean blood flow velocity after 30s of breath holding was lower in both WCH (5.3±3.1%) and SH (9.5±2.6%) groups indicating lower vasodilatory reactivity compared to healthy adolescents (12.1±2.2%). Additionally, serum nitric oxide (NOx) concentrations were lower in both WCH (30.6±11μM) and SH (30.7±22.4μM) groups compared to controls (38.8±7.6μM). Conclusions: Both white coat and sustained hypertension result in decreased vasodilatory reaction to CO2 in adolescents, suggesting involvement of the cerebral arterioles. The present study underlines the importance of early recognition and proper treatment of adolescent hypertension in order to prevent long-term cardiovascular complications.

AB - Background and purpose: Although its incidence is not high, adolescent hypertension may predict hypertension and increased cardiovascular risk in adulthood. Therefore, the aim of the present study was to assess whether cerebrovascular reactivity is altered in adolescent white coat and sustained hypertensive patients compared to healthy teenagers. Methods: Fifty-nine normotensive, 47 white coat hypertensive (WCH), and 73 sustained hypertensive (SH) adolescents were studied. WCH and SH were differentiated by ambulatory blood pressure monitoring. Cerebrovascular reactivity was assessed by transcranial Doppler breath-holding test and was expressed in percent (%) change to the resting cerebral blood flow velocity value. Results: The percent increase in middle cerebral artery mean blood flow velocity after 30s of breath holding was lower in both WCH (5.3±3.1%) and SH (9.5±2.6%) groups indicating lower vasodilatory reactivity compared to healthy adolescents (12.1±2.2%). Additionally, serum nitric oxide (NOx) concentrations were lower in both WCH (30.6±11μM) and SH (30.7±22.4μM) groups compared to controls (38.8±7.6μM). Conclusions: Both white coat and sustained hypertension result in decreased vasodilatory reaction to CO2 in adolescents, suggesting involvement of the cerebral arterioles. The present study underlines the importance of early recognition and proper treatment of adolescent hypertension in order to prevent long-term cardiovascular complications.

KW - Adolescent hypertension

KW - Cerebral vasoreactivity

KW - Transcranial Doppler sonography

KW - White coat and sustained hypertension

UR - http://www.scopus.com/inward/record.url?scp=79952719839&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952719839&partnerID=8YFLogxK

U2 - 10.1111/j.1468-1331.2010.03209.x

DO - 10.1111/j.1468-1331.2010.03209.x

M3 - Article

VL - 18

SP - 584

EP - 589

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 4

ER -