Impaired bronchomotor responses to field stimulation in guinea-pigs with cisplatin-induced neuropathy

Judith Szilvássy, I. Sziklai, Tamas Racz, Peter Horvath, Gyorgy Rabloczky, Z. Szilvássy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Pre-treatment with cisplatin (3 mg/kg) i.p. once a day over 6 days induced sensory neuropathy as confirmed by femoral nerve conduction velocity test and significantly decreased contractions induced by electrical field stimulation (100 stimuli, 20 V, 0.1 ms, 20 Hz) in isolated main bronchial rings from guinea-pigs. The field stimulation-induced non-adrenergic, non- cholinergic (NANC) relaxations, however, were amplified in rings from animals with cisplatin neuropathy. The NANC relaxation response was completely blocked by 30 μM N(G)-nitro-L-arginine methyl ester in preparations from both control and cisplatin-treated animals. Superoxide dismutase (40 units/ml) was without effect on NANC relaxation in control rings, however, it substantially decreased NANC relaxation in preparations from animals with cisplatin neuropathy. These results show that cisplatin-induced sensory neuropathy is accompanied by attenuation of neural bronchoconstriction and an enhanced NANC relaxation. The latter is in part attained by an increased peripheral superoxide production. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)259-265
Number of pages7
JournalEuropean Journal of Pharmacology
Volume403
Issue number3
DOIs
Publication statusPublished - Sep 8 2000

Fingerprint

Cholinergic Agents
Cisplatin
Guinea Pigs
Femoral Nerve
Bronchoconstriction
Neural Conduction
NG-Nitroarginine Methyl Ester
Superoxides
Electric Stimulation
Superoxide Dismutase

Keywords

  • Cisplatin
  • Peroxinitrite
  • Sensory neuropathy
  • Superoxide production

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Impaired bronchomotor responses to field stimulation in guinea-pigs with cisplatin-induced neuropathy. / Szilvássy, Judith; Sziklai, I.; Racz, Tamas; Horvath, Peter; Rabloczky, Gyorgy; Szilvássy, Z.

In: European Journal of Pharmacology, Vol. 403, No. 3, 08.09.2000, p. 259-265.

Research output: Contribution to journalArticle

Szilvássy, Judith ; Sziklai, I. ; Racz, Tamas ; Horvath, Peter ; Rabloczky, Gyorgy ; Szilvássy, Z. / Impaired bronchomotor responses to field stimulation in guinea-pigs with cisplatin-induced neuropathy. In: European Journal of Pharmacology. 2000 ; Vol. 403, No. 3. pp. 259-265.
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