Impaired and repaired inhibitory circuits in the epileptic human hippocampus

Research output: Contribution to journalReview article

140 Citations (Scopus)

Abstract

This review focuses on the epileptic human temporal lobe, primarily on recent findings related to changes in hippocampal GABAergic interneuron circuits that have a central role in epileptogenesis. Relying on correlations to animal studies, we provide a functional interpretation of the different changes in perisomatic inhibition (controlling output synchrony) and dendritic inhibition (controlling input plasticity), and the potential consequences of the loss of interneuron-selective interneurons. The highly heterogeneous, but specific, alterations of GABAergic interneuron circuits have important implications for the pharmacotherapy of epilepsy.

Original languageEnglish
Pages (from-to)334-340
Number of pages7
JournalTrends in Neurosciences
Volume28
Issue number6 SPEC. ISS.
DOIs
Publication statusPublished - Jun 2005

ASJC Scopus subject areas

  • Neuroscience(all)

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