Impaired and repaired inhibitory circuits in the epileptic human hippocampus

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

This review focuses on the epileptic human temporal lobe, primarily on recent findings related to changes in hippocampal GABAergic interneuron circuits that have a central role in epileptogenesis. Relying on correlations to animal studies, we provide a functional interpretation of the different changes in perisomatic inhibition (controlling output synchrony) and dendritic inhibition (controlling input plasticity), and the potential consequences of the loss of interneuron-selective interneurons. The highly heterogeneous, but specific, alterations of GABAergic interneuron circuits have important implications for the pharmacotherapy of epilepsy.

Original languageEnglish
Pages (from-to)334-340
Number of pages7
JournalTrends in Neurosciences
Volume28
Issue number6 SPEC. ISS.
DOIs
Publication statusPublished - Jun 2005

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Interneurons
Hippocampus
Temporal Lobe
Epilepsy
Drug Therapy

ASJC Scopus subject areas

  • Neuroscience(all)

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Impaired and repaired inhibitory circuits in the epileptic human hippocampus. / Maglóczky, Z.; Freund, T.

In: Trends in Neurosciences, Vol. 28, No. 6 SPEC. ISS., 06.2005, p. 334-340.

Research output: Contribution to journalArticle

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