Impaired and repaired inhibitory circuits in the epileptic human hippocampus

Research output: Contribution to journalReview article

140 Citations (Scopus)


This review focuses on the epileptic human temporal lobe, primarily on recent findings related to changes in hippocampal GABAergic interneuron circuits that have a central role in epileptogenesis. Relying on correlations to animal studies, we provide a functional interpretation of the different changes in perisomatic inhibition (controlling output synchrony) and dendritic inhibition (controlling input plasticity), and the potential consequences of the loss of interneuron-selective interneurons. The highly heterogeneous, but specific, alterations of GABAergic interneuron circuits have important implications for the pharmacotherapy of epilepsy.

Original languageEnglish
Pages (from-to)334-340
Number of pages7
JournalTrends in Neurosciences
Issue number6 SPEC. ISS.
Publication statusPublished - Jun 2005

ASJC Scopus subject areas

  • Neuroscience(all)

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