Impact of supplemental oxygen in mechanically ventilated adult and infant mice

Vincenzo Cannizzaro, Luke J. Berry, Graeme R. Zosky, Debra J. Turner, Z. Hantos, Peter D. Sly

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The aim of the present study was to determine the short-term effects of hyperoxia on respiratory mechanics in mechanically ventilated infant and adult mice. Eight and two week old BALB/c mice were exposed to inspired oxygen fractions (F IO2) of 0.21, 0.3, 0.6, and 1.0, respectively, during 120 min of mechanical ventilation. Respiratory system mechanics and inflammatory responses were measured. Using the low-frequency forced oscillation technique no differences were found in airway resistance between different F IO2 groups when corrected for changes in gas viscosity. Coefficients of lung tissue damping and elastance were not different between groups and showed similar changes over time in both age groups. Inflammatory responses did not differ between groups at either age. Hyperoxia had no impact on respiratory mechanics during mechanical ventilation with low tidal volume and positive end-expiratory pressure. Hence, supplemental oxygen can safely be applied during short-term mechanical ventilation strategies in infant and adult mice.

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalRespiratory Physiology and Neurobiology
Volume165
Issue number1
DOIs
Publication statusPublished - Jan 1 2009

Fingerprint

Respiratory Mechanics
Artificial Respiration
Hyperoxia
Oxygen
Airway Resistance
Positive-Pressure Respiration
Tidal Volume
Viscosity
Respiratory System
Age Groups
Gases
Lung

Keywords

  • Airway smooth muscle tone
  • Gas viscosity
  • Hyperoxia
  • Hyperoxia-induced lung injury
  • Infant mouse model
  • Respiratory system mechanics

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

Cite this

Impact of supplemental oxygen in mechanically ventilated adult and infant mice. / Cannizzaro, Vincenzo; Berry, Luke J.; Zosky, Graeme R.; Turner, Debra J.; Hantos, Z.; Sly, Peter D.

In: Respiratory Physiology and Neurobiology, Vol. 165, No. 1, 01.01.2009, p. 61-66.

Research output: Contribution to journalArticle

Cannizzaro, Vincenzo ; Berry, Luke J. ; Zosky, Graeme R. ; Turner, Debra J. ; Hantos, Z. ; Sly, Peter D. / Impact of supplemental oxygen in mechanically ventilated adult and infant mice. In: Respiratory Physiology and Neurobiology. 2009 ; Vol. 165, No. 1. pp. 61-66.
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