Impact of sorafenib dosing on outcome from the European patient subset of the GIDEON study

Bruno Daniele, Adina Croitoru, Christos Papandreou, Jean Pierre Bronowicki, Philippe Mathurin, Fatima Serejo, Per Stål, Juan Turnes, Vlad Ratziu, György Bodoky

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

SUMMARY Aims: To evaluate sorafenib dosing and safety in the Global Investigation of therapeutic GIDEON study's European subpopulation. Patients & methods: Patient demographics, disease characteristics and treatment history were recorded at enrollment; dose, adverse events and efficacy were recorded at follow-up. Results: Of 1113 evaluable patients, 82% started on 800 mg/day sorafenib; patients starting on 400 mg/day were slightly older, had baseline characteristics indicative of greater disease progression and higher adverse events incidences (96 vs 88%). Treatment duration (18.0 vs 13.0 weeks) and median overall survival (12.1 vs 9.4 months) were longer in patients receiving 800 mg/day. Conclusion: Imbalances in independent predictive factors may have led to longer survival in patients receiving 800 mg/day sorafenib; nonetheless, results suggest that the majority can start on this dose.

Original languageEnglish
Pages (from-to)2553-2562
Number of pages10
JournalFuture Oncology
Volume11
Issue number18
DOIs
Publication statusPublished - Sep 1 2015

Keywords

  • GIDEON
  • dosing
  • safety
  • sorafenib
  • unresectable hepatocellular carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Daniele, B., Croitoru, A., Papandreou, C., Bronowicki, J. P., Mathurin, P., Serejo, F., Stål, P., Turnes, J., Ratziu, V., & Bodoky, G. (2015). Impact of sorafenib dosing on outcome from the European patient subset of the GIDEON study. Future Oncology, 11(18), 2553-2562. https://doi.org/10.2217/fon.15.163