Impact of physical activity and cardiovascular fitness on total homocysteine concentrations in European adolescents: The HELENA study

Jasmin Benser, Jara Valtueña, Jonatan R. Ruiz, Juan Mielgo-Ayuso, Christina Breidenassel, German Vicente-Rodriguez, Marika Ferrari, Kurt Widhalm, Yannis Manios, Michael Sjöström, Denes Molnar, Sonia Gómez-Martínez, Antony Kafatos, Gonzalo Palacios, Luis A. Moreno, Manuel J. Castillo, Peter Stehle, Marcela González-Gross, Study Group Helena Study Group, Fréderic GottrandStefaan De Henauw, Marcela González-Gross, Chantal Gilbert, Anthony Kafatos, Christian Libersa, Jackie Sánchez, Mathilde Kersting, Michael Sjöstrom, Dénes Molnár, Jean Dallongeville, Gunnar Hall, Lea Maes, Luca Scalfi, Pilar Meléndez, Jesús Fleta, José A. Casajús, Gerardo Rodríguez, Concepción Tomás, María I. Mesana, Germán Vicente-Rodríguez, Adoración Villarroya, Carlos M. Gil, Ignacio Ara, Juan Revenga, Carmen Lachen, Juan Fernández Alvira, Gloria Bueno, Aurora Lázaro, Olga Bueno, Juan F. León, Jesús Ma Garagorri, Manuel Bueno, Juan Pablo Rey López, Iris Iglesia, Paula Velasco, Silvia Bel, Ascensión Marcos, Julia Wärnberg, Esther Nova, Sonia Gómez-Martínez, Esperanza Ligia Díaz, Javier Romeo, Ana Veses, Mari Angeles Puertollano, Belén Zapatera, Tamara Pozo, Laurent Beghin, Christian Libersa, Frédéric Gottrand, Catalina Iliescu, Juliana Von Berlepsch, Mathilde Kersting, Wolfgang Sichert-Hellert, Ellen Koeppen, Dénes Molnar, Eva Erhardt, Katalin Csernus, Katalin Török, Szilvia Bokor, Angster, Enikö Nagy, Orsolya Kovács, Judit Répasi, Anthony Kafatos, Caroline Codrington, María Plada, Angeliki Papadaki, Katerina Sarri, Anna Viskadourou, Christos Hatzis, Michael Kiriakakis, George Tsibinos, Constantine Vardavas Manolis Sbokos, Eva Protoyeraki, Maria Fasoulaki, Peter Stehle, Klaus Pietrzik, Marcela González-Gross, Christina Breidenassel, Andre Spinneker, Jasmin Al-Tahan, Miriam Segoviano, Anke Berchtold, Christine Bierschbach, Erika Blatzheim, Adelheid Schuch, Petra Pickert, Manuel J.Castillo Garzón, Ángel Gutiérrez Sáinz, Francisco B.Ortega Porcel, Jonatan Ruiz Ruiz, Enrique García Artero, Vanesa España Romero, David Jiménez Pavón, Cristóbal Sánchez Muñoz, Victor Soto, Palma Chillón, Jose M. Heredia, Virginia Aparicio, Pedro Baena, Claudia M. Cardia, Ana Carbonell, Davide Arcella, Elena Azzini, Emma Barrison, Noemi Bevilacqua, Pasquale Buonocore, Giovina Catasta, Laura Censi, Donatella Ciarapica, Paola D’Acapito, Marika Ferrari, Myriam Galfo, Cinzia Le Donne, Catherine Leclercq, Giuseppe Maiani, Beatrice Mauro, Lorenza Mistura, Antonella Pasquali, Raffaela Piccinelli, Angela Polito, Raffaella Spada, Stefania Sette, Maria Zaccaria, Luca Scalfi, Paola Vitaglione, Concetta Montagnese, Ilse De Bourdeaudhuij, Stefaan De Henauw, Tineke De Vriendt, Lea Maes, Christophe Matthys, Carine Vereecken, Mieke De Maeyer, Charlene Ottevaere, Inge Huybrechts, Kurt Widhalm, Sabine Dietrich, Yannis Manios, Eva Grammatikaki, Zoi Bouloubasi, Tina Louisa Cook, Sofia Eleutheriou, Orsalia Consta, George Moschonis, Ioanna Katsaroli, George Kraniou, Stalo Papoutsou, Despoina Keke, Ioanna Petraki, Elena Bellou, Sofia Tanagra, Kostalenia Kallianoti, Dionysia Argyropoulou, Katerina Kondaki, Stamatoula Tsikrika, Christos Karaiskos, Jean Dallongeville, Aline Meirhaeghe, Michael Sjöstrom, Patrick Bergman, María Hagströmer, Lena Hallström, Mårten Hallberg, Eric Poortvliet, Julia Wärnberg, Nico Rizzo, Linda Beckman, Anita Hurtig Wennlöf, Emma Patterson, Lydia Kwak, Lars Cernerud, Per Tillgren, Stefaan Sörensen, Jackie Sánchez-Molero, Elena Picó, Maite Navarro, Blanca Viadel, José Enrique Carreres, Gema Merino, Rosa Sanjuán, María Lorente, María José Sánchez, Sara Castelló, Chantal Gilbert, Sarah Thomas, Elaine Allchurch, Peter Burguess, Gunnar Hall, Annika Astrom, Anna Sverkén, Agneta Broberg, Annick Masson, Claire Lehoux, Pascal Brabant, Philippe Pate, Laurence Fontaine, Andras Sebok, Tunde Kuti, Adrienn Hegyi, Cristina Maldonado, Ana Llorente, Emilio García, Holger Von Fircks, Marianne Lilja Hallberg, Maria Messerer, Mats Larsson, Helena Fredriksson, Viola Adamsson, Ingmar Börjesson, Laura Fernández, Laura Smillie, Josephine Wills, Marcela González-Gross, Jara Valtueña, Raquel Pedrero-Chamizo, Gonzalo Palacios, Agustín Meléndez, Pedro J. Benito, Juan José Gómez Lorente, David Cañada, Alejandro Urzanqui, Juan Carlos Ortiz, Francisco Fuentes, David Jiménez-Pavón, Ulrike Albers, Juan Mielgo Ayuso, Rosa María Torres, Paloma Navarro

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We examined the association of physical activity (PA), cardiovascular fitness (CVF) and fatness with total homocysteine (tHcy) concentrations in European adolescents. The present study comprised 713 European adolescents aged 14.8±1.2 y (females 55.3%) from the multicenter HELENA cross-sectional study. PA was assessed through accelerometry, CVF by the 20-m shuttle run test, and body fat by skinfold thicknesses with the Slaughter equation. Plasma folate, cobalamin, and tHcy concentrations were measured. To examine the association of tHcy with PA, CVF, and fatness after controlling for a set of confounders including age, maturity, folate, cobalamin, creatinine, smoking, supplement use, and methylenetetrahydrofolate reductase 677 genotype (CC 47%, CT 43%, TT 10%), bivariate correlations followed by multiple regression models were performed. In the bivariate correlation analysis, tHcy concentrations were slightly negatively correlated (p<0.0 5) with CVF in females (measured both by stages: r=-0.118 and by VO2max: r=-0.10 2) and positively with body mass index (r=0.10 0). However, daily time spent with moderate and vigorous PA showed a weak positive association with tHcy in females (p<0.0 5). tHcy concentrations showed a tendency to decrease with increasing CVF and increase with increasing BMI in female European adolescents. However, tHcy concentrations were positively associated with moderate and vigorous PA in female European adolescents.

Original languageEnglish
Pages (from-to)45-54
Number of pages10
JournalJournal of Nutritional Science and Vitaminology
Volume61
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

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Keywords

  • Body constitution
  • Cardiovascular fitness
  • Homocysteine
  • Physical activity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Benser, J., Valtueña, J., Ruiz, J. R., Mielgo-Ayuso, J., Breidenassel, C., Vicente-Rodriguez, G., Ferrari, M., Widhalm, K., Manios, Y., Sjöström, M., Molnar, D., Gómez-Martínez, S., Kafatos, A., Palacios, G., Moreno, L. A., Castillo, M. J., Stehle, P., González-Gross, M., Helena Study Group, S. G., ... Navarro, P. (2015). Impact of physical activity and cardiovascular fitness on total homocysteine concentrations in European adolescents: The HELENA study. Journal of Nutritional Science and Vitaminology, 61(1), 45-54. https://doi.org/10.3177/jnsv.61.45