Impact of physical activity and cardiovascular fitness on total homocysteine concentrations in European adolescents

The HELENA study

Jasmin Benser, Jara Valtueña, Jonatan R. Ruiz, Juan Mielgo-Ayuso, Christina Breidenassel, German Vicente-Rodriguez, Marika Ferrari, Kurt Widhalm, Yannis Manios, Michael Sjöström, D. Molnár, Sonia Gómez-Martínez, Antony Kafatos, Gonzalo Palacios, Luis A. Moreno, Manuel J. Castillo, Peter Stehle, Marcela González-Gross, Study Group Helena Study Group, Fréderic Gottrand & 229 others Stefaan De Henauw, Marcela González-Gross, Chantal Gilbert, Anthony Kafatos, Christian Libersa, Jackie Sánchez, Mathilde Kersting, Michael Sjöstrom, Dénes Molnár, Jean Dallongeville, Gunnar Hall, Lea Maes, Luca Scalfi, Pilar Meléndez, Jesús Fleta, José A. Casajús, Gerardo Rodríguez, Concepción Tomás, María I. Mesana, Germán Vicente-Rodríguez, Adoración Villarroya, Carlos M. Gil, Ignacio Ara, Juan Revenga, Carmen Lachen, Juan Fernández Alvira, Gloria Bueno, Aurora Lázaro, Olga Bueno, Juan F. León, Jesús Ma Garagorri, Manuel Bueno, Juan Pablo Rey López, Iris Iglesia, Paula Velasco, Silvia Bel, Ascensión Marcos, Julia Wärnberg, Esther Nova, Sonia Gómez-Martínez, Esperanza Ligia Díaz, Javier Romeo, Ana Veses, Mari Angeles Puertollano, Belén Zapatera, Tamara Pozo, Laurent Beghin, Christian Libersa, Frédéric Gottrand, Catalina Iliescu, Juliana Von Berlepsch, Mathilde Kersting, Wolfgang Sichert-Hellert, Ellen Koeppen, Dénes Molnar, E. Erhardt, Katalin Csernus, Katalin Török, Szilvia Bokor, Angster, Enikö Nagy, Orsolya Kovács, Judit Répasi, Anthony Kafatos, Caroline Codrington, María Plada, Angeliki Papadaki, Katerina Sarri, Anna Viskadourou, Christos Hatzis, Michael Kiriakakis, George Tsibinos, Constantine Vardavas Manolis Sbokos, Eva Protoyeraki, Maria Fasoulaki, Peter Stehle, Klaus Pietrzik, Marcela González-Gross, Christina Breidenassel, Andre Spinneker, Jasmin Al-Tahan, Miriam Segoviano, Anke Berchtold, Christine Bierschbach, Erika Blatzheim, Adelheid Schuch, Petra Pickert, Manuel J Castillo Garzón, Ángel Gutiérrez Sáinz, Francisco B Ortega Porcel, Jonatan Ruiz Ruiz, Enrique García Artero, Vanesa España Romero, David Jiménez Pavón, Cristóbal Sánchez Muñoz, Victor Soto, Palma Chillón, Jose M. Heredia, Virginia Aparicio, Pedro Baena, Claudia M. Cardia, Ana Carbonell, Davide Arcella, Elena Azzini, Emma Barrison, Noemi Bevilacqua, Pasquale Buonocore, Giovina Catasta, Laura Censi, Donatella Ciarapica, Paola D’Acapito, Marika Ferrari, Myriam Galfo, Cinzia Le Donne, Catherine Leclercq, Giuseppe Maiani, Beatrice Mauro, Lorenza Mistura, Antonella Pasquali, Raffaela Piccinelli, Angela Polito, Raffaella Spada, Stefania Sette, Maria Zaccaria, Luca Scalfi, Paola Vitaglione, Concetta Montagnese, Ilse De Bourdeaudhuij, Stefaan De Henauw, Tineke De Vriendt, Lea Maes, Christophe Matthys, Carine Vereecken, Mieke De Maeyer, Charlene Ottevaere, Inge Huybrechts, Kurt Widhalm, Sabine Dietrich, Yannis Manios, Eva Grammatikaki, Zoi Bouloubasi, Tina Louisa Cook, Sofia Eleutheriou, Orsalia Consta, George Moschonis, Ioanna Katsaroli, George Kraniou, Stalo Papoutsou, Despoina Keke, Ioanna Petraki, Elena Bellou, Sofia Tanagra, Kostalenia Kallianoti, Dionysia Argyropoulou, Katerina Kondaki, Stamatoula Tsikrika, Christos Karaiskos, Jean Dallongeville, Aline Meirhaeghe, Michael Sjöstrom, Patrick Bergman, María Hagströmer, Lena Hallström, Mårten Hallberg, Eric Poortvliet, Julia Wärnberg, Nico Rizzo, Linda Beckman, Anita Hurtig Wennlöf, Emma Patterson, Lydia Kwak, Lars Cernerud, Per Tillgren, Stefaan Sörensen, Jackie Sánchez-Molero, Elena Picó, Maite Navarro, Blanca Viadel, José Enrique Carreres, Gema Merino, Rosa Sanjuán, María Lorente, María José Sánchez, Sara Castelló, Chantal Gilbert, Sarah Thomas, Elaine Allchurch, Peter Burguess, Gunnar Hall, Annika Astrom, Anna Sverkén, Agneta Broberg, Annick Masson, Claire Lehoux, Pascal Brabant, Philippe Pate, Laurence Fontaine, Andras Sebok, Tunde Kuti, Adrienn Hegyi, Cristina Maldonado, Ana Llorente, Emilio García, Holger Von Fircks, Marianne Lilja Hallberg, Maria Messerer, Mats Larsson, Helena Fredriksson, Viola Adamsson, Ingmar Börjesson, Laura Fernández, Laura Smillie, Josephine Wills, Marcela González-Gross, Jara Valtueña, Raquel Pedrero-Chamizo, Gonzalo Palacios, Agustín Meléndez, Pedro J. Benito, Juan José Gómez Lorente, David Cañada, Alejandro Urzanqui, Juan Carlos Ortiz, Francisco Fuentes, David Jiménez-Pavón, Ulrike Albers, Juan Mielgo Ayuso, Rosa María Torres, Paloma Navarro

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We examined the association of physical activity (PA), cardiovascular fitness (CVF) and fatness with total homocysteine (tHcy) concentrations in European adolescents. The present study comprised 713 European adolescents aged 14.8±1.2 y (females 55.3%) from the multicenter HELENA cross-sectional study. PA was assessed through accelerometry, CVF by the 20-m shuttle run test, and body fat by skinfold thicknesses with the Slaughter equation. Plasma folate, cobalamin, and tHcy concentrations were measured. To examine the association of tHcy with PA, CVF, and fatness after controlling for a set of confounders including age, maturity, folate, cobalamin, creatinine, smoking, supplement use, and methylenetetrahydrofolate reductase 677 genotype (CC 47%, CT 43%, TT 10%), bivariate correlations followed by multiple regression models were performed. In the bivariate correlation analysis, tHcy concentrations were slightly negatively correlated (p2max: r=-0.10 2) and positively with body mass index (r=0.10 0). However, daily time spent with moderate and vigorous PA showed a weak positive association with tHcy in females (p

Original languageEnglish
Pages (from-to)45-54
Number of pages10
JournalJournal of Nutritional Science and Vitaminology
Volume61
Issue number1
Publication statusPublished - 2015

Fingerprint

Homocysteine
Exercise
Vitamin B 12
Folic Acid
Accelerometry
Methylenetetrahydrofolate Reductase (NADPH2)
Skinfold Thickness
Adipose Tissue
Creatinine
Body Mass Index
Cross-Sectional Studies
Smoking
Genotype

Keywords

  • Body constitution
  • Cardiovascular fitness
  • Homocysteine
  • Physical activity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Benser, J., Valtueña, J., Ruiz, J. R., Mielgo-Ayuso, J., Breidenassel, C., Vicente-Rodriguez, G., ... Navarro, P. (2015). Impact of physical activity and cardiovascular fitness on total homocysteine concentrations in European adolescents: The HELENA study. Journal of Nutritional Science and Vitaminology, 61(1), 45-54.

Impact of physical activity and cardiovascular fitness on total homocysteine concentrations in European adolescents : The HELENA study. / Benser, Jasmin; Valtueña, Jara; Ruiz, Jonatan R.; Mielgo-Ayuso, Juan; Breidenassel, Christina; Vicente-Rodriguez, German; Ferrari, Marika; Widhalm, Kurt; Manios, Yannis; Sjöström, Michael; Molnár, D.; Gómez-Martínez, Sonia; Kafatos, Antony; Palacios, Gonzalo; Moreno, Luis A.; Castillo, Manuel J.; Stehle, Peter; González-Gross, Marcela; Helena Study Group, Study Group; Gottrand, Fréderic; De Henauw, Stefaan; González-Gross, Marcela; Gilbert, Chantal; Kafatos, Anthony; Libersa, Christian; Sánchez, Jackie; Kersting, Mathilde; Sjöstrom, Michael; Molnár, Dénes; Dallongeville, Jean; Hall, Gunnar; Maes, Lea; Scalfi, Luca; Meléndez, Pilar; Fleta, Jesús; Casajús, José A.; Rodríguez, Gerardo; Tomás, Concepción; Mesana, María I.; Vicente-Rodríguez, Germán; Villarroya, Adoración; Gil, Carlos M.; Ara, Ignacio; Revenga, Juan; Lachen, Carmen; Alvira, Juan Fernández; Bueno, Gloria; Lázaro, Aurora; Bueno, Olga; León, Juan F.; Garagorri, Jesús Ma; Bueno, Manuel; López, Juan Pablo Rey; Iglesia, Iris; Velasco, Paula; Bel, Silvia; Marcos, Ascensión; Wärnberg, Julia; Nova, Esther; Gómez-Martínez, Sonia; Díaz, Esperanza Ligia; Romeo, Javier; Veses, Ana; Puertollano, Mari Angeles; Zapatera, Belén; Pozo, Tamara; Beghin, Laurent; Libersa, Christian; Gottrand, Frédéric; Iliescu, Catalina; Von Berlepsch, Juliana; Kersting, Mathilde; Sichert-Hellert, Wolfgang; Koeppen, Ellen; Molnar, Dénes; Erhardt, E.; Csernus, Katalin; Török, Katalin; Bokor, Szilvia; Angster; Nagy, Enikö; Kovács, Orsolya; Répasi, Judit; Kafatos, Anthony; Codrington, Caroline; Plada, María; Papadaki, Angeliki; Sarri, Katerina; Viskadourou, Anna; Hatzis, Christos; Kiriakakis, Michael; Tsibinos, George; Sbokos, Constantine Vardavas Manolis; Protoyeraki, Eva; Fasoulaki, Maria; Stehle, Peter; Pietrzik, Klaus; González-Gross, Marcela; Breidenassel, Christina; Spinneker, Andre; Al-Tahan, Jasmin; Segoviano, Miriam; Berchtold, Anke; Bierschbach, Christine; Blatzheim, Erika; Schuch, Adelheid; Pickert, Petra; Garzón, Manuel J Castillo; Sáinz, Ángel Gutiérrez; Porcel, Francisco B Ortega; Ruiz, Jonatan Ruiz; Artero, Enrique García; Romero, Vanesa España; Pavón, David Jiménez; Muñoz, Cristóbal Sánchez; Soto, Victor; Chillón, Palma; Heredia, Jose M.; Aparicio, Virginia; Baena, Pedro; Cardia, Claudia M.; Carbonell, Ana; Arcella, Davide; Azzini, Elena; Barrison, Emma; Bevilacqua, Noemi; Buonocore, Pasquale; Catasta, Giovina; Censi, Laura; Ciarapica, Donatella; D’Acapito, Paola; Ferrari, Marika; Galfo, Myriam; Le Donne, Cinzia; Leclercq, Catherine; Maiani, Giuseppe; Mauro, Beatrice; Mistura, Lorenza; Pasquali, Antonella; Piccinelli, Raffaela; Polito, Angela; Spada, Raffaella; Sette, Stefania; Zaccaria, Maria; Scalfi, Luca; Vitaglione, Paola; Montagnese, Concetta; De Bourdeaudhuij, Ilse; De Henauw, Stefaan; De Vriendt, Tineke; Maes, Lea; Matthys, Christophe; Vereecken, Carine; De Maeyer, Mieke; Ottevaere, Charlene; Huybrechts, Inge; Widhalm, Kurt; Dietrich, Sabine; Manios, Yannis; Grammatikaki, Eva; Bouloubasi, Zoi; Cook, Tina Louisa; Eleutheriou, Sofia; Consta, Orsalia; Moschonis, George; Katsaroli, Ioanna; Kraniou, George; Papoutsou, Stalo; Keke, Despoina; Petraki, Ioanna; Bellou, Elena; Tanagra, Sofia; Kallianoti, Kostalenia; Argyropoulou, Dionysia; Kondaki, Katerina; Tsikrika, Stamatoula; Karaiskos, Christos; Dallongeville, Jean; Meirhaeghe, Aline; Sjöstrom, Michael; Bergman, Patrick; Hagströmer, María; Hallström, Lena; Hallberg, Mårten; Poortvliet, Eric; Wärnberg, Julia; Rizzo, Nico; Beckman, Linda; Wennlöf, Anita Hurtig; Patterson, Emma; Kwak, Lydia; Cernerud, Lars; Tillgren, Per; Sörensen, Stefaan; Sánchez-Molero, Jackie; Picó, Elena; Navarro, Maite; Viadel, Blanca; Carreres, José Enrique; Merino, Gema; Sanjuán, Rosa; Lorente, María; Sánchez, María José; Castelló, Sara; Gilbert, Chantal; Thomas, Sarah; Allchurch, Elaine; Burguess, Peter; Hall, Gunnar; Astrom, Annika; Sverkén, Anna; Broberg, Agneta; Masson, Annick; Lehoux, Claire; Brabant, Pascal; Pate, Philippe; Fontaine, Laurence; Sebok, Andras; Kuti, Tunde; Hegyi, Adrienn; Maldonado, Cristina; Llorente, Ana; García, Emilio; Von Fircks, Holger; Hallberg, Marianne Lilja; Messerer, Maria; Larsson, Mats; Fredriksson, Helena; Adamsson, Viola; Börjesson, Ingmar; Fernández, Laura; Smillie, Laura; Wills, Josephine; González-Gross, Marcela; Valtueña, Jara; Pedrero-Chamizo, Raquel; Palacios, Gonzalo; Meléndez, Agustín; Benito, Pedro J.; Lorente, Juan José Gómez; Cañada, David; Urzanqui, Alejandro; Ortiz, Juan Carlos; Fuentes, Francisco; Jiménez-Pavón, David; Albers, Ulrike; Ayuso, Juan Mielgo; Torres, Rosa María; Navarro, Paloma.

In: Journal of Nutritional Science and Vitaminology, Vol. 61, No. 1, 2015, p. 45-54.

Research output: Contribution to journalArticle

Benser, J, Valtueña, J, Ruiz, JR, Mielgo-Ayuso, J, Breidenassel, C, Vicente-Rodriguez, G, Ferrari, M, Widhalm, K, Manios, Y, Sjöström, M, Molnár, D, Gómez-Martínez, S, Kafatos, A, Palacios, G, Moreno, LA, Castillo, MJ, Stehle, P, González-Gross, M, Helena Study Group, SG, Gottrand, F, De Henauw, S, González-Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, JA, Rodríguez, G, Tomás, C, Mesana, MI, Vicente-Rodríguez, G, Villarroya, A, Gil, CM, Ara, I, Revenga, J, Lachen, C, Alvira, JF, Bueno, G, Lázaro, A, Bueno, O, León, JF, Garagorri, JM, Bueno, M, López, JPR, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez-Martínez, S, Díaz, EL, Romeo, J, Veses, A, Puertollano, MA, Zapatera, B, Pozo, T, Beghin, L, Libersa, C, Gottrand, F, Iliescu, C, Von Berlepsch, J, Kersting, M, Sichert-Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Répasi, J, Kafatos, A, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Sbokos, CVM, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, González-Gross, M, Breidenassel, C, Spinneker, A, Al-Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Garzón, MJC, Sáinz, ÁG, Porcel, FBO, Ruiz, JR, Artero, EG, Romero, VE, Pavón, DJ, Muñoz, CS, Soto, V, Chillón, P, Heredia, JM, Aparicio, V, Baena, P, Cardia, CM, Carbonell, A, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D’Acapito, P, Ferrari, M, Galfo, M, Le Donne, C, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Scalfi, L, Vitaglione, P, Montagnese, C, De Bourdeaudhuij, I, De Henauw, S, De Vriendt, T, Maes, L, Matthys, C, Vereecken, C, De Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Dietrich, S, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, TL, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Dallongeville, J, Meirhaeghe, A, Sjöstrom, M, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Wärnberg, J, Rizzo, N, Beckman, L, Wennlöf, AH, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez-Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, JE, Merino, G, Sanjuán, R, Lorente, M, Sánchez, MJ, Castelló, S, Gilbert, C, Thomas, S, Allchurch, E, Burguess, P, Hall, G, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, Von Fircks, H, Hallberg, ML, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, González-Gross, M, Valtueña, J, Pedrero-Chamizo, R, Palacios, G, Meléndez, A, Benito, PJ, Lorente, JJG, Cañada, D, Urzanqui, A, Ortiz, JC, Fuentes, F, Jiménez-Pavón, D, Albers, U, Ayuso, JM, Torres, RM & Navarro, P 2015, 'Impact of physical activity and cardiovascular fitness on total homocysteine concentrations in European adolescents: The HELENA study', Journal of Nutritional Science and Vitaminology, vol. 61, no. 1, pp. 45-54.
Benser, Jasmin ; Valtueña, Jara ; Ruiz, Jonatan R. ; Mielgo-Ayuso, Juan ; Breidenassel, Christina ; Vicente-Rodriguez, German ; Ferrari, Marika ; Widhalm, Kurt ; Manios, Yannis ; Sjöström, Michael ; Molnár, D. ; Gómez-Martínez, Sonia ; Kafatos, Antony ; Palacios, Gonzalo ; Moreno, Luis A. ; Castillo, Manuel J. ; Stehle, Peter ; González-Gross, Marcela ; Helena Study Group, Study Group ; Gottrand, Fréderic ; De Henauw, Stefaan ; González-Gross, Marcela ; Gilbert, Chantal ; Kafatos, Anthony ; Libersa, Christian ; Sánchez, Jackie ; Kersting, Mathilde ; Sjöstrom, Michael ; Molnár, Dénes ; Dallongeville, Jean ; Hall, Gunnar ; Maes, Lea ; Scalfi, Luca ; Meléndez, Pilar ; Fleta, Jesús ; Casajús, José A. ; Rodríguez, Gerardo ; Tomás, Concepción ; Mesana, María I. ; Vicente-Rodríguez, Germán ; Villarroya, Adoración ; Gil, Carlos M. ; Ara, Ignacio ; Revenga, Juan ; Lachen, Carmen ; Alvira, Juan Fernández ; Bueno, Gloria ; Lázaro, Aurora ; Bueno, Olga ; León, Juan F. ; Garagorri, Jesús Ma ; Bueno, Manuel ; López, Juan Pablo Rey ; Iglesia, Iris ; Velasco, Paula ; Bel, Silvia ; Marcos, Ascensión ; Wärnberg, Julia ; Nova, Esther ; Gómez-Martínez, Sonia ; Díaz, Esperanza Ligia ; Romeo, Javier ; Veses, Ana ; Puertollano, Mari Angeles ; Zapatera, Belén ; Pozo, Tamara ; Beghin, Laurent ; Libersa, Christian ; Gottrand, Frédéric ; Iliescu, Catalina ; Von Berlepsch, Juliana ; Kersting, Mathilde ; Sichert-Hellert, Wolfgang ; Koeppen, Ellen ; Molnar, Dénes ; Erhardt, E. ; Csernus, Katalin ; Török, Katalin ; Bokor, Szilvia ; Angster ; Nagy, Enikö ; Kovács, Orsolya ; Répasi, Judit ; Kafatos, Anthony ; Codrington, Caroline ; Plada, María ; Papadaki, Angeliki ; Sarri, Katerina ; Viskadourou, Anna ; Hatzis, Christos ; Kiriakakis, Michael ; Tsibinos, George ; Sbokos, Constantine Vardavas Manolis ; Protoyeraki, Eva ; Fasoulaki, Maria ; Stehle, Peter ; Pietrzik, Klaus ; González-Gross, Marcela ; Breidenassel, Christina ; Spinneker, Andre ; Al-Tahan, Jasmin ; Segoviano, Miriam ; Berchtold, Anke ; Bierschbach, Christine ; Blatzheim, Erika ; Schuch, Adelheid ; Pickert, Petra ; Garzón, Manuel J Castillo ; Sáinz, Ángel Gutiérrez ; Porcel, Francisco B Ortega ; Ruiz, Jonatan Ruiz ; Artero, Enrique García ; Romero, Vanesa España ; Pavón, David Jiménez ; Muñoz, Cristóbal Sánchez ; Soto, Victor ; Chillón, Palma ; Heredia, Jose M. ; Aparicio, Virginia ; Baena, Pedro ; Cardia, Claudia M. ; Carbonell, Ana ; Arcella, Davide ; Azzini, Elena ; Barrison, Emma ; Bevilacqua, Noemi ; Buonocore, Pasquale ; Catasta, Giovina ; Censi, Laura ; Ciarapica, Donatella ; D’Acapito, Paola ; Ferrari, Marika ; Galfo, Myriam ; Le Donne, Cinzia ; Leclercq, Catherine ; Maiani, Giuseppe ; Mauro, Beatrice ; Mistura, Lorenza ; Pasquali, Antonella ; Piccinelli, Raffaela ; Polito, Angela ; Spada, Raffaella ; Sette, Stefania ; Zaccaria, Maria ; Scalfi, Luca ; Vitaglione, Paola ; Montagnese, Concetta ; De Bourdeaudhuij, Ilse ; De Henauw, Stefaan ; De Vriendt, Tineke ; Maes, Lea ; Matthys, Christophe ; Vereecken, Carine ; De Maeyer, Mieke ; Ottevaere, Charlene ; Huybrechts, Inge ; Widhalm, Kurt ; Dietrich, Sabine ; Manios, Yannis ; Grammatikaki, Eva ; Bouloubasi, Zoi ; Cook, Tina Louisa ; Eleutheriou, Sofia ; Consta, Orsalia ; Moschonis, George ; Katsaroli, Ioanna ; Kraniou, George ; Papoutsou, Stalo ; Keke, Despoina ; Petraki, Ioanna ; Bellou, Elena ; Tanagra, Sofia ; Kallianoti, Kostalenia ; Argyropoulou, Dionysia ; Kondaki, Katerina ; Tsikrika, Stamatoula ; Karaiskos, Christos ; Dallongeville, Jean ; Meirhaeghe, Aline ; Sjöstrom, Michael ; Bergman, Patrick ; Hagströmer, María ; Hallström, Lena ; Hallberg, Mårten ; Poortvliet, Eric ; Wärnberg, Julia ; Rizzo, Nico ; Beckman, Linda ; Wennlöf, Anita Hurtig ; Patterson, Emma ; Kwak, Lydia ; Cernerud, Lars ; Tillgren, Per ; Sörensen, Stefaan ; Sánchez-Molero, Jackie ; Picó, Elena ; Navarro, Maite ; Viadel, Blanca ; Carreres, José Enrique ; Merino, Gema ; Sanjuán, Rosa ; Lorente, María ; Sánchez, María José ; Castelló, Sara ; Gilbert, Chantal ; Thomas, Sarah ; Allchurch, Elaine ; Burguess, Peter ; Hall, Gunnar ; Astrom, Annika ; Sverkén, Anna ; Broberg, Agneta ; Masson, Annick ; Lehoux, Claire ; Brabant, Pascal ; Pate, Philippe ; Fontaine, Laurence ; Sebok, Andras ; Kuti, Tunde ; Hegyi, Adrienn ; Maldonado, Cristina ; Llorente, Ana ; García, Emilio ; Von Fircks, Holger ; Hallberg, Marianne Lilja ; Messerer, Maria ; Larsson, Mats ; Fredriksson, Helena ; Adamsson, Viola ; Börjesson, Ingmar ; Fernández, Laura ; Smillie, Laura ; Wills, Josephine ; González-Gross, Marcela ; Valtueña, Jara ; Pedrero-Chamizo, Raquel ; Palacios, Gonzalo ; Meléndez, Agustín ; Benito, Pedro J. ; Lorente, Juan José Gómez ; Cañada, David ; Urzanqui, Alejandro ; Ortiz, Juan Carlos ; Fuentes, Francisco ; Jiménez-Pavón, David ; Albers, Ulrike ; Ayuso, Juan Mielgo ; Torres, Rosa María ; Navarro, Paloma. / Impact of physical activity and cardiovascular fitness on total homocysteine concentrations in European adolescents : The HELENA study. In: Journal of Nutritional Science and Vitaminology. 2015 ; Vol. 61, No. 1. pp. 45-54.
@article{7733a0c91f574782a668d02a8735b1de,
title = "Impact of physical activity and cardiovascular fitness on total homocysteine concentrations in European adolescents: The HELENA study",
abstract = "We examined the association of physical activity (PA), cardiovascular fitness (CVF) and fatness with total homocysteine (tHcy) concentrations in European adolescents. The present study comprised 713 European adolescents aged 14.8±1.2 y (females 55.3{\%}) from the multicenter HELENA cross-sectional study. PA was assessed through accelerometry, CVF by the 20-m shuttle run test, and body fat by skinfold thicknesses with the Slaughter equation. Plasma folate, cobalamin, and tHcy concentrations were measured. To examine the association of tHcy with PA, CVF, and fatness after controlling for a set of confounders including age, maturity, folate, cobalamin, creatinine, smoking, supplement use, and methylenetetrahydrofolate reductase 677 genotype (CC 47{\%}, CT 43{\%}, TT 10{\%}), bivariate correlations followed by multiple regression models were performed. In the bivariate correlation analysis, tHcy concentrations were slightly negatively correlated (p2max: r=-0.10 2) and positively with body mass index (r=0.10 0). However, daily time spent with moderate and vigorous PA showed a weak positive association with tHcy in females (p",
keywords = "Body constitution, Cardiovascular fitness, Homocysteine, Physical activity",
author = "Jasmin Benser and Jara Valtue{\~n}a and Ruiz, {Jonatan R.} and Juan Mielgo-Ayuso and Christina Breidenassel and German Vicente-Rodriguez and Marika Ferrari and Kurt Widhalm and Yannis Manios and Michael Sj{\"o}str{\"o}m and D. Moln{\'a}r and Sonia G{\'o}mez-Mart{\'i}nez and Antony Kafatos and Gonzalo Palacios and Moreno, {Luis A.} and Castillo, {Manuel J.} and Peter Stehle and Marcela Gonz{\'a}lez-Gross and {Helena Study Group}, {Study Group} and Fr{\'e}deric Gottrand and {De Henauw}, Stefaan and Marcela Gonz{\'a}lez-Gross and Chantal Gilbert and Anthony Kafatos and Christian Libersa and Jackie S{\'a}nchez and Mathilde Kersting and Michael Sj{\"o}strom and D{\'e}nes Moln{\'a}r and Jean Dallongeville and Gunnar Hall and Lea Maes and Luca Scalfi and Pilar Mel{\'e}ndez and Jes{\'u}s Fleta and Casaj{\'u}s, {Jos{\'e} A.} and Gerardo Rodr{\'i}guez and Concepci{\'o}n Tom{\'a}s and Mesana, {Mar{\'i}a I.} and Germ{\'a}n Vicente-Rodr{\'i}guez and Adoraci{\'o}n Villarroya and Gil, {Carlos M.} and Ignacio Ara and Juan Revenga and Carmen Lachen and Alvira, {Juan Fern{\'a}ndez} and Gloria Bueno and Aurora L{\'a}zaro and Olga Bueno and Le{\'o}n, {Juan F.} and Garagorri, {Jes{\'u}s Ma} and Manuel Bueno and L{\'o}pez, {Juan Pablo Rey} and Iris Iglesia and Paula Velasco and Silvia Bel and Ascensi{\'o}n Marcos and Julia W{\"a}rnberg and Esther Nova and Sonia G{\'o}mez-Mart{\'i}nez and D{\'i}az, {Esperanza Ligia} and Javier Romeo and Ana Veses and Puertollano, {Mari Angeles} and Bel{\'e}n Zapatera and Tamara Pozo and Laurent Beghin and Christian Libersa and Fr{\'e}d{\'e}ric Gottrand and Catalina Iliescu and {Von Berlepsch}, Juliana and Mathilde Kersting and Wolfgang Sichert-Hellert and Ellen Koeppen and D{\'e}nes Molnar and E. Erhardt and Katalin Csernus and Katalin T{\"o}r{\"o}k and Szilvia Bokor and Angster and Enik{\"o} Nagy and Orsolya Kov{\'a}cs and Judit R{\'e}pasi and Anthony Kafatos and Caroline Codrington and Mar{\'i}a Plada and Angeliki Papadaki and Katerina Sarri and Anna Viskadourou and Christos Hatzis and Michael Kiriakakis and George Tsibinos and Sbokos, {Constantine Vardavas Manolis} and Eva Protoyeraki and Maria Fasoulaki and Peter Stehle and Klaus Pietrzik and Marcela Gonz{\'a}lez-Gross and Christina Breidenassel and Andre Spinneker and Jasmin Al-Tahan and Miriam Segoviano and Anke Berchtold and Christine Bierschbach and Erika Blatzheim and Adelheid Schuch and Petra Pickert and Garz{\'o}n, {Manuel J Castillo} and S{\'a}inz, {{\'A}ngel Guti{\'e}rrez} and Porcel, {Francisco B Ortega} and Ruiz, {Jonatan Ruiz} and Artero, {Enrique Garc{\'i}a} and Romero, {Vanesa Espa{\~n}a} and Pav{\'o}n, {David Jim{\'e}nez} and Mu{\~n}oz, {Crist{\'o}bal S{\'a}nchez} and Victor Soto and Palma Chill{\'o}n and Heredia, {Jose M.} and Virginia Aparicio and Pedro Baena and Cardia, {Claudia M.} and Ana Carbonell and Davide Arcella and Elena Azzini and Emma Barrison and Noemi Bevilacqua and Pasquale Buonocore and Giovina Catasta and Laura Censi and Donatella Ciarapica and Paola D’Acapito and Marika Ferrari and Myriam Galfo and {Le Donne}, Cinzia and Catherine Leclercq and Giuseppe Maiani and Beatrice Mauro and Lorenza Mistura and Antonella Pasquali and Raffaela Piccinelli and Angela Polito and Raffaella Spada and Stefania Sette and Maria Zaccaria and Luca Scalfi and Paola Vitaglione and Concetta Montagnese and {De Bourdeaudhuij}, Ilse and {De Henauw}, Stefaan and {De Vriendt}, Tineke and Lea Maes and Christophe Matthys and Carine Vereecken and {De Maeyer}, Mieke and Charlene Ottevaere and Inge Huybrechts and Kurt Widhalm and Sabine Dietrich and Yannis Manios and Eva Grammatikaki and Zoi Bouloubasi and Cook, {Tina Louisa} and Sofia Eleutheriou and Orsalia Consta and George Moschonis and Ioanna Katsaroli and George Kraniou and Stalo Papoutsou and Despoina Keke and Ioanna Petraki and Elena Bellou and Sofia Tanagra and Kostalenia Kallianoti and Dionysia Argyropoulou and Katerina Kondaki and Stamatoula Tsikrika and Christos Karaiskos and Jean Dallongeville and Aline Meirhaeghe and Michael Sj{\"o}strom and Patrick Bergman and Mar{\'i}a Hagstr{\"o}mer and Lena Hallstr{\"o}m and M{\aa}rten Hallberg and Eric Poortvliet and Julia W{\"a}rnberg and Nico Rizzo and Linda Beckman and Wennl{\"o}f, {Anita Hurtig} and Emma Patterson and Lydia Kwak and Lars Cernerud and Per Tillgren and Stefaan S{\"o}rensen and Jackie S{\'a}nchez-Molero and Elena Pic{\'o} and Maite Navarro and Blanca Viadel and Carreres, {Jos{\'e} Enrique} and Gema Merino and Rosa Sanju{\'a}n and Mar{\'i}a Lorente and S{\'a}nchez, {Mar{\'i}a Jos{\'e}} and Sara Castell{\'o} and Chantal Gilbert and Sarah Thomas and Elaine Allchurch and Peter Burguess and Gunnar Hall and Annika Astrom and Anna Sverk{\'e}n and Agneta Broberg and Annick Masson and Claire Lehoux and Pascal Brabant and Philippe Pate and Laurence Fontaine and Andras Sebok and Tunde Kuti and Adrienn Hegyi and Cristina Maldonado and Ana Llorente and Emilio Garc{\'i}a and {Von Fircks}, Holger and Hallberg, {Marianne Lilja} and Maria Messerer and Mats Larsson and Helena Fredriksson and Viola Adamsson and Ingmar B{\"o}rjesson and Laura Fern{\'a}ndez and Laura Smillie and Josephine Wills and Marcela Gonz{\'a}lez-Gross and Jara Valtue{\~n}a and Raquel Pedrero-Chamizo and Gonzalo Palacios and Agust{\'i}n Mel{\'e}ndez and Benito, {Pedro J.} and Lorente, {Juan Jos{\'e} G{\'o}mez} and David Ca{\~n}ada and Alejandro Urzanqui and Ortiz, {Juan Carlos} and Francisco Fuentes and David Jim{\'e}nez-Pav{\'o}n and Ulrike Albers and Ayuso, {Juan Mielgo} and Torres, {Rosa Mar{\'i}a} and Paloma Navarro",
year = "2015",
language = "English",
volume = "61",
pages = "45--54",
journal = "Journal of Nutritional Science and Vitaminology",
issn = "0301-4800",
publisher = "Center for Academic Publications Japan",
number = "1",

}

TY - JOUR

T1 - Impact of physical activity and cardiovascular fitness on total homocysteine concentrations in European adolescents

T2 - The HELENA study

AU - Benser, Jasmin

AU - Valtueña, Jara

AU - Ruiz, Jonatan R.

AU - Mielgo-Ayuso, Juan

AU - Breidenassel, Christina

AU - Vicente-Rodriguez, German

AU - Ferrari, Marika

AU - Widhalm, Kurt

AU - Manios, Yannis

AU - Sjöström, Michael

AU - Molnár, D.

AU - Gómez-Martínez, Sonia

AU - Kafatos, Antony

AU - Palacios, Gonzalo

AU - Moreno, Luis A.

AU - Castillo, Manuel J.

AU - Stehle, Peter

AU - González-Gross, Marcela

AU - Helena Study Group, Study Group

AU - Gottrand, Fréderic

AU - De Henauw, Stefaan

AU - González-Gross, Marcela

AU - Gilbert, Chantal

AU - Kafatos, Anthony

AU - Libersa, Christian

AU - Sánchez, Jackie

AU - Kersting, Mathilde

AU - Sjöstrom, Michael

AU - Molnár, Dénes

AU - Dallongeville, Jean

AU - Hall, Gunnar

AU - Maes, Lea

AU - Scalfi, Luca

AU - Meléndez, Pilar

AU - Fleta, Jesús

AU - Casajús, José A.

AU - Rodríguez, Gerardo

AU - Tomás, Concepción

AU - Mesana, María I.

AU - Vicente-Rodríguez, Germán

AU - Villarroya, Adoración

AU - Gil, Carlos M.

AU - Ara, Ignacio

AU - Revenga, Juan

AU - Lachen, Carmen

AU - Alvira, Juan Fernández

AU - Bueno, Gloria

AU - Lázaro, Aurora

AU - Bueno, Olga

AU - León, Juan F.

AU - Garagorri, Jesús Ma

AU - Bueno, Manuel

AU - López, Juan Pablo Rey

AU - Iglesia, Iris

AU - Velasco, Paula

AU - Bel, Silvia

AU - Marcos, Ascensión

AU - Wärnberg, Julia

AU - Nova, Esther

AU - Gómez-Martínez, Sonia

AU - Díaz, Esperanza Ligia

AU - Romeo, Javier

AU - Veses, Ana

AU - Puertollano, Mari Angeles

AU - Zapatera, Belén

AU - Pozo, Tamara

AU - Beghin, Laurent

AU - Libersa, Christian

AU - Gottrand, Frédéric

AU - Iliescu, Catalina

AU - Von Berlepsch, Juliana

AU - Kersting, Mathilde

AU - Sichert-Hellert, Wolfgang

AU - Koeppen, Ellen

AU - Molnar, Dénes

AU - Erhardt, E.

AU - Csernus, Katalin

AU - Török, Katalin

AU - Bokor, Szilvia

AU - Angster,

AU - Nagy, Enikö

AU - Kovács, Orsolya

AU - Répasi, Judit

AU - Kafatos, Anthony

AU - Codrington, Caroline

AU - Plada, María

AU - Papadaki, Angeliki

AU - Sarri, Katerina

AU - Viskadourou, Anna

AU - Hatzis, Christos

AU - Kiriakakis, Michael

AU - Tsibinos, George

AU - Sbokos, Constantine Vardavas Manolis

AU - Protoyeraki, Eva

AU - Fasoulaki, Maria

AU - Stehle, Peter

AU - Pietrzik, Klaus

AU - González-Gross, Marcela

AU - Breidenassel, Christina

AU - Spinneker, Andre

AU - Al-Tahan, Jasmin

AU - Segoviano, Miriam

AU - Berchtold, Anke

AU - Bierschbach, Christine

AU - Blatzheim, Erika

AU - Schuch, Adelheid

AU - Pickert, Petra

AU - Garzón, Manuel J Castillo

AU - Sáinz, Ángel Gutiérrez

AU - Porcel, Francisco B Ortega

AU - Ruiz, Jonatan Ruiz

AU - Artero, Enrique García

AU - Romero, Vanesa España

AU - Pavón, David Jiménez

AU - Muñoz, Cristóbal Sánchez

AU - Soto, Victor

AU - Chillón, Palma

AU - Heredia, Jose M.

AU - Aparicio, Virginia

AU - Baena, Pedro

AU - Cardia, Claudia M.

AU - Carbonell, Ana

AU - Arcella, Davide

AU - Azzini, Elena

AU - Barrison, Emma

AU - Bevilacqua, Noemi

AU - Buonocore, Pasquale

AU - Catasta, Giovina

AU - Censi, Laura

AU - Ciarapica, Donatella

AU - D’Acapito, Paola

AU - Ferrari, Marika

AU - Galfo, Myriam

AU - Le Donne, Cinzia

AU - Leclercq, Catherine

AU - Maiani, Giuseppe

AU - Mauro, Beatrice

AU - Mistura, Lorenza

AU - Pasquali, Antonella

AU - Piccinelli, Raffaela

AU - Polito, Angela

AU - Spada, Raffaella

AU - Sette, Stefania

AU - Zaccaria, Maria

AU - Scalfi, Luca

AU - Vitaglione, Paola

AU - Montagnese, Concetta

AU - De Bourdeaudhuij, Ilse

AU - De Henauw, Stefaan

AU - De Vriendt, Tineke

AU - Maes, Lea

AU - Matthys, Christophe

AU - Vereecken, Carine

AU - De Maeyer, Mieke

AU - Ottevaere, Charlene

AU - Huybrechts, Inge

AU - Widhalm, Kurt

AU - Dietrich, Sabine

AU - Manios, Yannis

AU - Grammatikaki, Eva

AU - Bouloubasi, Zoi

AU - Cook, Tina Louisa

AU - Eleutheriou, Sofia

AU - Consta, Orsalia

AU - Moschonis, George

AU - Katsaroli, Ioanna

AU - Kraniou, George

AU - Papoutsou, Stalo

AU - Keke, Despoina

AU - Petraki, Ioanna

AU - Bellou, Elena

AU - Tanagra, Sofia

AU - Kallianoti, Kostalenia

AU - Argyropoulou, Dionysia

AU - Kondaki, Katerina

AU - Tsikrika, Stamatoula

AU - Karaiskos, Christos

AU - Dallongeville, Jean

AU - Meirhaeghe, Aline

AU - Sjöstrom, Michael

AU - Bergman, Patrick

AU - Hagströmer, María

AU - Hallström, Lena

AU - Hallberg, Mårten

AU - Poortvliet, Eric

AU - Wärnberg, Julia

AU - Rizzo, Nico

AU - Beckman, Linda

AU - Wennlöf, Anita Hurtig

AU - Patterson, Emma

AU - Kwak, Lydia

AU - Cernerud, Lars

AU - Tillgren, Per

AU - Sörensen, Stefaan

AU - Sánchez-Molero, Jackie

AU - Picó, Elena

AU - Navarro, Maite

AU - Viadel, Blanca

AU - Carreres, José Enrique

AU - Merino, Gema

AU - Sanjuán, Rosa

AU - Lorente, María

AU - Sánchez, María José

AU - Castelló, Sara

AU - Gilbert, Chantal

AU - Thomas, Sarah

AU - Allchurch, Elaine

AU - Burguess, Peter

AU - Hall, Gunnar

AU - Astrom, Annika

AU - Sverkén, Anna

AU - Broberg, Agneta

AU - Masson, Annick

AU - Lehoux, Claire

AU - Brabant, Pascal

AU - Pate, Philippe

AU - Fontaine, Laurence

AU - Sebok, Andras

AU - Kuti, Tunde

AU - Hegyi, Adrienn

AU - Maldonado, Cristina

AU - Llorente, Ana

AU - García, Emilio

AU - Von Fircks, Holger

AU - Hallberg, Marianne Lilja

AU - Messerer, Maria

AU - Larsson, Mats

AU - Fredriksson, Helena

AU - Adamsson, Viola

AU - Börjesson, Ingmar

AU - Fernández, Laura

AU - Smillie, Laura

AU - Wills, Josephine

AU - González-Gross, Marcela

AU - Valtueña, Jara

AU - Pedrero-Chamizo, Raquel

AU - Palacios, Gonzalo

AU - Meléndez, Agustín

AU - Benito, Pedro J.

AU - Lorente, Juan José Gómez

AU - Cañada, David

AU - Urzanqui, Alejandro

AU - Ortiz, Juan Carlos

AU - Fuentes, Francisco

AU - Jiménez-Pavón, David

AU - Albers, Ulrike

AU - Ayuso, Juan Mielgo

AU - Torres, Rosa María

AU - Navarro, Paloma

PY - 2015

Y1 - 2015

N2 - We examined the association of physical activity (PA), cardiovascular fitness (CVF) and fatness with total homocysteine (tHcy) concentrations in European adolescents. The present study comprised 713 European adolescents aged 14.8±1.2 y (females 55.3%) from the multicenter HELENA cross-sectional study. PA was assessed through accelerometry, CVF by the 20-m shuttle run test, and body fat by skinfold thicknesses with the Slaughter equation. Plasma folate, cobalamin, and tHcy concentrations were measured. To examine the association of tHcy with PA, CVF, and fatness after controlling for a set of confounders including age, maturity, folate, cobalamin, creatinine, smoking, supplement use, and methylenetetrahydrofolate reductase 677 genotype (CC 47%, CT 43%, TT 10%), bivariate correlations followed by multiple regression models were performed. In the bivariate correlation analysis, tHcy concentrations were slightly negatively correlated (p2max: r=-0.10 2) and positively with body mass index (r=0.10 0). However, daily time spent with moderate and vigorous PA showed a weak positive association with tHcy in females (p

AB - We examined the association of physical activity (PA), cardiovascular fitness (CVF) and fatness with total homocysteine (tHcy) concentrations in European adolescents. The present study comprised 713 European adolescents aged 14.8±1.2 y (females 55.3%) from the multicenter HELENA cross-sectional study. PA was assessed through accelerometry, CVF by the 20-m shuttle run test, and body fat by skinfold thicknesses with the Slaughter equation. Plasma folate, cobalamin, and tHcy concentrations were measured. To examine the association of tHcy with PA, CVF, and fatness after controlling for a set of confounders including age, maturity, folate, cobalamin, creatinine, smoking, supplement use, and methylenetetrahydrofolate reductase 677 genotype (CC 47%, CT 43%, TT 10%), bivariate correlations followed by multiple regression models were performed. In the bivariate correlation analysis, tHcy concentrations were slightly negatively correlated (p2max: r=-0.10 2) and positively with body mass index (r=0.10 0). However, daily time spent with moderate and vigorous PA showed a weak positive association with tHcy in females (p

KW - Body constitution

KW - Cardiovascular fitness

KW - Homocysteine

KW - Physical activity

UR - http://www.scopus.com/inward/record.url?scp=84929783061&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929783061&partnerID=8YFLogxK

M3 - Article

VL - 61

SP - 45

EP - 54

JO - Journal of Nutritional Science and Vitaminology

JF - Journal of Nutritional Science and Vitaminology

SN - 0301-4800

IS - 1

ER -