Impact of obesity and leptin levels on the secretion of estradiol, inhibin A and inhibin B during ovarian stimulation with gonadotropins

J. Urbancsek, P. Fedorcsák, K. Klinga, N. Dévényi, Z. Papp, T. Rabe, T. Strowitzki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We examined the impact of high leptin levels on the secretion of estradiol, inhibin A and inhibin B in obese and lean women during ovarian stimulation. Patients undergoing long-term pituitary suppression, ovarian stimulation and in vitro fertilization for non-endocrine reasons were included in this case-control study. Obese women (body mass index (BMI) > 28 kg/m2; n = 17) were individually matched with lean women (BMI 20-25 kg/m2; n = 17) for age and baseline follicle stimulating hormone and luteinizing hormone concentrations. Blood samples were collected in a previous menstrual cycle and 1-3 days apart throughout ovarian stimulation. Serum levels of estradiol, leptin, inhibin A and inhibin B were measured. Obese and lean women had similar serum concentrations of estradiol, inhibin A and inhibin B in the follicular and luteal phases of the spontaneous menstrual cycle, and throughout ovarian stimulation. Serum levels of leptin were higher in obese than in lean women, and increased during stimulation in both groups. In the obese group, area-under-the-curve (AUC) leptin levels correlated with AUC inhibin A levels. In the lean group, there was no correlation between AUC leptin levels and AUC levels of ovarian hormones. The results suggest that high leptin concentrations in vivo are not associated with impaired secretion of estradiol and dimeric inhibins during ovarian stimulation.

Original languageEnglish
Pages (from-to)285-292
Number of pages8
JournalGynecological Endocrinology
Volume16
Issue number4
Publication statusPublished - Aug 2002

Fingerprint

Ovulation Induction
Leptin
Gonadotropins
Estradiol
Obesity
Area Under Curve
Body Mass Index
Serum
Inhibins
Follicular Phase
Luteal Phase
Follicle Stimulating Hormone
Fertilization in Vitro
Menstrual Cycle
Luteinizing Hormone
inhibin A
inhibin B
Case-Control Studies
Hormones

Keywords

  • Inhibin A
  • Inhibin B
  • Leptin
  • Obesity
  • Ovarian stimulation

ASJC Scopus subject areas

  • Endocrinology
  • Obstetrics and Gynaecology

Cite this

Impact of obesity and leptin levels on the secretion of estradiol, inhibin A and inhibin B during ovarian stimulation with gonadotropins. / Urbancsek, J.; Fedorcsák, P.; Klinga, K.; Dévényi, N.; Papp, Z.; Rabe, T.; Strowitzki, T.

In: Gynecological Endocrinology, Vol. 16, No. 4, 08.2002, p. 285-292.

Research output: Contribution to journalArticle

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