Impact of microvascular circulation on peripheral lung stability

F. Peták, Barna Babik, Z. Hantos, Denis R. Morel, Jean Claude Pache, Catherine Biton, Béla Suki, Walid Habre

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The involvement of pulmonary circulation in the mechanical properties was studied in isolated rat lungs. Pulmonary input impedance (ZL) was measured at a mean transpulmonary pressure (Ptpmean) of 2 cmH2O before and after physiological perfusion with either blood or albumin. In these lungs and in a group of unperfused lungs, ZL was also measured at Ptpmean values between 1 and 8 cmH2O. Airway resistance (Raw) and parenchymal damping (G) and elastance (H) were estimated from ZL. End-expiratory lung volume (EELV) was measured by immersion before and after blood perfusion. The orientation of the elastin fibers relative to the basal membrane was assessed in additional unperfused and blood-perfused lungs. Pressurization of the pulmonary capillaries significantly decreased H by 31.5 ± 3.7% and 18.7 ± 2.7% for blood and albumin, respectively. Perfusion had no effect on Raw but markedly altered the Ptpmean dependences of G and H 2O, with significantly lower values than in the unperfused lungs. At a Ptpmean of 2 cmH2O, EELV increased by 31 ± 11% (P = 0.01) following pressurization of the capillaries, and the elastin fibers became more parallel to the basal membrane. Because the organization of elastin fibers results in smaller H values of the individual alveolus, the higher H in the unperfused lungs is probably due to a partial alveolar collapse leading to a loss in lung volume. We conclude that the physiological pressure in the pulmonary capillaries is an important mechanical factor in the maintenance of the stability of the alveolar architecture.

Original languageEnglish
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume287
Issue number4 31-4
DOIs
Publication statusPublished - Oct 2004

Fingerprint

Lung
Elastin
Perfusion
Albumins
Pressure
Airway Resistance
Pulmonary Circulation
Membranes
Immersion
Electric Impedance
Maintenance

Keywords

  • Alveolar wall
  • Elastin
  • End-expiratory lung volume
  • Forced oscillations

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Cell Biology
  • Physiology

Cite this

Impact of microvascular circulation on peripheral lung stability. / Peták, F.; Babik, Barna; Hantos, Z.; Morel, Denis R.; Pache, Jean Claude; Biton, Catherine; Suki, Béla; Habre, Walid.

In: American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 287, No. 4 31-4, 10.2004.

Research output: Contribution to journalArticle

Peták, F. ; Babik, Barna ; Hantos, Z. ; Morel, Denis R. ; Pache, Jean Claude ; Biton, Catherine ; Suki, Béla ; Habre, Walid. / Impact of microvascular circulation on peripheral lung stability. In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 2004 ; Vol. 287, No. 4 31-4.
@article{4fb7e1eb339a4909b00fc319e9c90e3f,
title = "Impact of microvascular circulation on peripheral lung stability",
abstract = "The involvement of pulmonary circulation in the mechanical properties was studied in isolated rat lungs. Pulmonary input impedance (ZL) was measured at a mean transpulmonary pressure (Ptpmean) of 2 cmH2O before and after physiological perfusion with either blood or albumin. In these lungs and in a group of unperfused lungs, ZL was also measured at Ptpmean values between 1 and 8 cmH2O. Airway resistance (Raw) and parenchymal damping (G) and elastance (H) were estimated from ZL. End-expiratory lung volume (EELV) was measured by immersion before and after blood perfusion. The orientation of the elastin fibers relative to the basal membrane was assessed in additional unperfused and blood-perfused lungs. Pressurization of the pulmonary capillaries significantly decreased H by 31.5 ± 3.7{\%} and 18.7 ± 2.7{\%} for blood and albumin, respectively. Perfusion had no effect on Raw but markedly altered the Ptpmean dependences of G and H 2O, with significantly lower values than in the unperfused lungs. At a Ptpmean of 2 cmH2O, EELV increased by 31 ± 11{\%} (P = 0.01) following pressurization of the capillaries, and the elastin fibers became more parallel to the basal membrane. Because the organization of elastin fibers results in smaller H values of the individual alveolus, the higher H in the unperfused lungs is probably due to a partial alveolar collapse leading to a loss in lung volume. We conclude that the physiological pressure in the pulmonary capillaries is an important mechanical factor in the maintenance of the stability of the alveolar architecture.",
keywords = "Alveolar wall, Elastin, End-expiratory lung volume, Forced oscillations",
author = "F. Pet{\'a}k and Barna Babik and Z. Hantos and Morel, {Denis R.} and Pache, {Jean Claude} and Catherine Biton and B{\'e}la Suki and Walid Habre",
year = "2004",
month = "10",
doi = "10.1152/ajplung.00263.2003",
language = "English",
volume = "287",
journal = "American Journal of Physiology",
issn = "0363-6119",
publisher = "American Physiological Society",
number = "4 31-4",

}

TY - JOUR

T1 - Impact of microvascular circulation on peripheral lung stability

AU - Peták, F.

AU - Babik, Barna

AU - Hantos, Z.

AU - Morel, Denis R.

AU - Pache, Jean Claude

AU - Biton, Catherine

AU - Suki, Béla

AU - Habre, Walid

PY - 2004/10

Y1 - 2004/10

N2 - The involvement of pulmonary circulation in the mechanical properties was studied in isolated rat lungs. Pulmonary input impedance (ZL) was measured at a mean transpulmonary pressure (Ptpmean) of 2 cmH2O before and after physiological perfusion with either blood or albumin. In these lungs and in a group of unperfused lungs, ZL was also measured at Ptpmean values between 1 and 8 cmH2O. Airway resistance (Raw) and parenchymal damping (G) and elastance (H) were estimated from ZL. End-expiratory lung volume (EELV) was measured by immersion before and after blood perfusion. The orientation of the elastin fibers relative to the basal membrane was assessed in additional unperfused and blood-perfused lungs. Pressurization of the pulmonary capillaries significantly decreased H by 31.5 ± 3.7% and 18.7 ± 2.7% for blood and albumin, respectively. Perfusion had no effect on Raw but markedly altered the Ptpmean dependences of G and H 2O, with significantly lower values than in the unperfused lungs. At a Ptpmean of 2 cmH2O, EELV increased by 31 ± 11% (P = 0.01) following pressurization of the capillaries, and the elastin fibers became more parallel to the basal membrane. Because the organization of elastin fibers results in smaller H values of the individual alveolus, the higher H in the unperfused lungs is probably due to a partial alveolar collapse leading to a loss in lung volume. We conclude that the physiological pressure in the pulmonary capillaries is an important mechanical factor in the maintenance of the stability of the alveolar architecture.

AB - The involvement of pulmonary circulation in the mechanical properties was studied in isolated rat lungs. Pulmonary input impedance (ZL) was measured at a mean transpulmonary pressure (Ptpmean) of 2 cmH2O before and after physiological perfusion with either blood or albumin. In these lungs and in a group of unperfused lungs, ZL was also measured at Ptpmean values between 1 and 8 cmH2O. Airway resistance (Raw) and parenchymal damping (G) and elastance (H) were estimated from ZL. End-expiratory lung volume (EELV) was measured by immersion before and after blood perfusion. The orientation of the elastin fibers relative to the basal membrane was assessed in additional unperfused and blood-perfused lungs. Pressurization of the pulmonary capillaries significantly decreased H by 31.5 ± 3.7% and 18.7 ± 2.7% for blood and albumin, respectively. Perfusion had no effect on Raw but markedly altered the Ptpmean dependences of G and H 2O, with significantly lower values than in the unperfused lungs. At a Ptpmean of 2 cmH2O, EELV increased by 31 ± 11% (P = 0.01) following pressurization of the capillaries, and the elastin fibers became more parallel to the basal membrane. Because the organization of elastin fibers results in smaller H values of the individual alveolus, the higher H in the unperfused lungs is probably due to a partial alveolar collapse leading to a loss in lung volume. We conclude that the physiological pressure in the pulmonary capillaries is an important mechanical factor in the maintenance of the stability of the alveolar architecture.

KW - Alveolar wall

KW - Elastin

KW - End-expiratory lung volume

KW - Forced oscillations

UR - http://www.scopus.com/inward/record.url?scp=4544352742&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4544352742&partnerID=8YFLogxK

U2 - 10.1152/ajplung.00263.2003

DO - 10.1152/ajplung.00263.2003

M3 - Article

C2 - 15208092

AN - SCOPUS:4544352742

VL - 287

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0363-6119

IS - 4 31-4

ER -