Impact of histamine on dendritic cell functions

Tünde Simon, V. László, A. Falus

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A rapidly growing body of evidence highlighted that histamine, a small biogenic amine, is implicated in the regulation of DC(dendritic cell) functions. It is well established that DCs represent the most potent antigen-presenting cells of the body,linking innate and acquired immunity and regulating the outcome of immune responses. Signals, associated with ongoinginflammation and uptake of foreign antigens, promote maturation of DCs and activation of T-cell responses in secondarylymphatic organs. These bone marrow-derived cells patrol continuously all over the body. During their persistent migration,several mediators may influence the behaviour and functions of DCs. Histamine, produced by mast cells, basophils or DCsthemselves, may have an important role in the life cycle of DCs. From the differentiation, through their never-endingcirculation, until the induction of T-cell response, histamine is present and influences the life cycle of DCs. Here, we summarize recent progress in histamine research with respect to DC functions. We also point out some controversialaspects of histamine action on DCs.

Original languageEnglish
Pages (from-to)997-1000
Number of pages4
JournalCell Biology International
Volume35
Issue number10
DOIs
Publication statusPublished - Oct 1 2011

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Dendritic Cells
Histamine
Life Cycle Stages
T-Lymphocytes
Biogenic Amines
Basophils
Adaptive Immunity
Antigen-Presenting Cells
Innate Immunity
Mast Cells
Bone Marrow Cells
Antigens
Research

Keywords

  • Antigen presentation
  • Dendritic cell (DC) differentiation
  • Histamine
  • Migration
  • T-cell polarization

ASJC Scopus subject areas

  • Cell Biology

Cite this

Impact of histamine on dendritic cell functions. / Simon, Tünde; László, V.; Falus, A.

In: Cell Biology International, Vol. 35, No. 10, 01.10.2011, p. 997-1000.

Research output: Contribution to journalArticle

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