Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice

M. Oksman, H. Iivonen, E. Hogyes, Z. Amtul, B. Penke, I. Leenders, L. Broersen, D. Lütjohann, T. Hartmann, H. Tanila

Research output: Contribution to journalArticle

223 Citations (Scopus)

Abstract

The present study assessed the influence of dietary lipids on accumulation of amyloid beta-peptide (Aβ) in the brain. Seven experimental diets with varying n-6/n-3-ratio, saturated and polyunsaturated fatty acid and cholesterol contents were fed to transgenic APPswe/PS1dE9 mice for 3-4 months beginning at a young adult age (6 months). Hippocampal Aβ levels were determined with ELISA and plaque load by using immunocytochemistry. A typical Western diet with 40% saturated fatty acids and 1% of cholesterol increased, while diets supplemented with docosahexaenoic acid (DHA) decreased Aβ levels compared to regular (soy oil based) diet. DHA diet also decreased the number of activated microglia in hippocampus and increased exploratory activity of transgenic mice, but did not improve their spatial learning in the water maze. The favorable effect of DHA on Aβ production was verified in two different cell lines. Regulation of dietary lipid intake may offer a new tool to reduce the risk of Alzheimer's disease at the population level.

Original languageEnglish
Pages (from-to)563-572
Number of pages10
JournalNeurobiology of Disease
Volume23
Issue number3
DOIs
Publication statusPublished - Sep 2006

Fingerprint

Unsaturated Fatty Acids
Amyloid
Transgenic Mice
Docosahexaenoic Acids
Fatty Acids
Cholesterol
Diet
Lipids
Amyloid beta-Peptides
Microglia
Young Adult
Hippocampus
Alzheimer Disease
Oils
Enzyme-Linked Immunosorbent Assay
Immunohistochemistry
Cell Line
Water
Brain
Population

Keywords

  • Alzheimer's disease
  • Amyloid plaque
  • DHA
  • Lipid
  • n-3
  • Omega-3
  • PUFA

ASJC Scopus subject areas

  • Neurology

Cite this

Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice. / Oksman, M.; Iivonen, H.; Hogyes, E.; Amtul, Z.; Penke, B.; Leenders, I.; Broersen, L.; Lütjohann, D.; Hartmann, T.; Tanila, H.

In: Neurobiology of Disease, Vol. 23, No. 3, 09.2006, p. 563-572.

Research output: Contribution to journalArticle

Oksman, M. ; Iivonen, H. ; Hogyes, E. ; Amtul, Z. ; Penke, B. ; Leenders, I. ; Broersen, L. ; Lütjohann, D. ; Hartmann, T. ; Tanila, H. / Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice. In: Neurobiology of Disease. 2006 ; Vol. 23, No. 3. pp. 563-572.
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