Impact of CT-apelin and NT-proBNP on identifying non-responders to cardiac resynchronization therapy

Annamária Kosztin, Gábor Széplaki, Attila Kovács, Gábor Földes, István Szokodi, Klaudia Vivien Nagy, Valentina Kutyifa, Éva Fórizs, Eszter M. Végh, László Gellér, Dávid Becker, Dániel Aradi, Béla Merkely

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Abstract

Context: Assessment of response to cardiac resynchronization therapy (CRT) is essential. Objective: To assess the predictive value of CT-apelin together with NT-proBNP in patients undergoing CRT. Methods: Serum CT-apelin and NT-proBNP were measured by ELISA before, and six months after CRT. Primary endpoint was non-response (<4% increase in LVEF) after six months. Results: From 81 patients, 15 proved to be non-responders. Six-month CT-apelin was superior compared to NT-proBNP in identifying non-responders by multivariate ROC (CT-apelin: p = 0.01, NT-proBNP: p = 0.13) and by logistic regression (CT-apelin: p = 0.01, NT-proBNP: p = 0.41) analyses. Conclusion: Six-month CT-apelin might be a valuable novel biomarker in identifying non-responders to CRT that was superior to NT-proBNP.

Original languageEnglish
Pages (from-to)279-286
Number of pages8
JournalBiomarkers
Volume22
Issue number3-4
DOIs
Publication statusPublished - May 19 2017

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Keywords

  • CRT responder
  • Cardiovascular disease
  • NT-proBNP
  • apelin
  • renal disease

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

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