Impact of Body Mass Index on the One-Year Clinical Outcome of Patients Undergoing Multivessel Revascularization With Sirolimus-Eluting Stents (from the Arterial Revascularization Therapies Study Part II)†Conflicts of interest

Ahmed A. Khattab, Joost Daemen, Gert Richardt, Philippe Rioux, Franz Wolfgang Amann, Richard Levy, I. Horváth, Rui C. Teles, Fath Ordoubadi, Magdaleen Pieters, Kristel Wittebols, Hans Peter Stoll, Patrick W. Serruys

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The differential safety and efficacy profiles of sirolimus-eluting stents when implanted in patients with multivessel coronary artery disease who have increased body mass indexes (BMIs) compared with those with normal BMIs are largely unknown. This study evaluated the impact of BMI on 1-year outcomes in patients with multivessel coronary artery disease treated with sirolimus-eluting stents as part of the Arterial Revascularization Therapies Study Part II (ARTS II). From February to November 2003, 607 patients were included at 45 centers; 176 patients had normal BMIs (2), 289 were overweight (≥25 and ≤30 kg/m2), and 142 were obese (>30 kg/m2). At 30 days, the cumulative incidence of the primary combined end point of death, myocardial infarction, cerebrovascular accident, and repeat revascularization (major adverse cardiac and cerebrovascular events) was 3.4% in the group with normal BMIs, 3.1% in overweight patients, and 2.8% in obese patients (p = 0.76). At 1 year, the cumulative incidence of major adverse cardiac and cerebrovascular events was 10.8%, 11.8%, and 7.0% in the normal BMI, overweight, and obese groups, respectively (p = 0.31). In conclusion, BMI had no impact on 1-year clinical outcomes in patients with multivessel coronary artery disease treated with sirolimus-eluting stents in ARTS II.

Original languageEnglish
Pages (from-to)1550-1559
Number of pages10
JournalThe American journal of cardiology
Volume101
Issue number11
DOIs
Publication statusPublished - Jun 1 2008

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Conflict of Interest
Sirolimus
Stents
Body Mass Index
Coronary Artery Disease
Therapeutics
Incidence
Stroke
Myocardial Infarction
Safety

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Impact of Body Mass Index on the One-Year Clinical Outcome of Patients Undergoing Multivessel Revascularization With Sirolimus-Eluting Stents (from the Arterial Revascularization Therapies Study Part II)†Conflicts of interest. / Khattab, Ahmed A.; Daemen, Joost; Richardt, Gert; Rioux, Philippe; Amann, Franz Wolfgang; Levy, Richard; Horváth, I.; Teles, Rui C.; Ordoubadi, Fath; Pieters, Magdaleen; Wittebols, Kristel; Stoll, Hans Peter; Serruys, Patrick W.

In: The American journal of cardiology, Vol. 101, No. 11, 01.06.2008, p. 1550-1559.

Research output: Contribution to journalArticle

Khattab, Ahmed A. ; Daemen, Joost ; Richardt, Gert ; Rioux, Philippe ; Amann, Franz Wolfgang ; Levy, Richard ; Horváth, I. ; Teles, Rui C. ; Ordoubadi, Fath ; Pieters, Magdaleen ; Wittebols, Kristel ; Stoll, Hans Peter ; Serruys, Patrick W. / Impact of Body Mass Index on the One-Year Clinical Outcome of Patients Undergoing Multivessel Revascularization With Sirolimus-Eluting Stents (from the Arterial Revascularization Therapies Study Part II)†Conflicts of interest. In: The American journal of cardiology. 2008 ; Vol. 101, No. 11. pp. 1550-1559.
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abstract = "The differential safety and efficacy profiles of sirolimus-eluting stents when implanted in patients with multivessel coronary artery disease who have increased body mass indexes (BMIs) compared with those with normal BMIs are largely unknown. This study evaluated the impact of BMI on 1-year outcomes in patients with multivessel coronary artery disease treated with sirolimus-eluting stents as part of the Arterial Revascularization Therapies Study Part II (ARTS II). From February to November 2003, 607 patients were included at 45 centers; 176 patients had normal BMIs (2), 289 were overweight (≥25 and ≤30 kg/m2), and 142 were obese (>30 kg/m2). At 30 days, the cumulative incidence of the primary combined end point of death, myocardial infarction, cerebrovascular accident, and repeat revascularization (major adverse cardiac and cerebrovascular events) was 3.4{\%} in the group with normal BMIs, 3.1{\%} in overweight patients, and 2.8{\%} in obese patients (p = 0.76). At 1 year, the cumulative incidence of major adverse cardiac and cerebrovascular events was 10.8{\%}, 11.8{\%}, and 7.0{\%} in the normal BMI, overweight, and obese groups, respectively (p = 0.31). In conclusion, BMI had no impact on 1-year clinical outcomes in patients with multivessel coronary artery disease treated with sirolimus-eluting stents in ARTS II.",
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