Potentiometric and spectroscopic measurements have shown that Al3+ ions form 1:1 complexes with adriamycin and its analogues. The major complex at pH > 5 is a tetrahedral species in which the metal ion is co-ordinated to the ligand via two anthracycline oxygens. Two OH- groups complete the co-ordination sphere. Although the complexes are comparatively stable the formation of [Al(OH)4]- at pH > 8.5 excludes adriamycin from the metal ion co-ordination sites. The unusual fluorometric behaviour of the drug molecule is also present in the complex formed at lower pH.
|Number of pages||5|
|Journal||Journal of the Chemical Society, Dalton Transactions|
|Publication status||Published - Dec 1 1993|
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