Immunotoxicological investigation of subacute combined exposure with low doses of PB, HG and CD in rats

L. Institóris, Dóra Kovács, I. Kecskeméti-Kovács, Anita Lukács, A. Szabó, Zsuzsanna Lengyel, A. Papp, L. Nagymajtényi, I. Dési

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Detectable interactions between NOEL (No Observed Effect Level) doses of Pb, Hg and Cd in general toxicological, hematological, and immune function parameters were investigated. The metals (Pb-acetate, 20 mg/kg; HgCl 2, 0.40 mg/kg; CdCl2, 1.61 mg/kg) were combined. First, the rats received the combination Pb + Hg + Cd for 4 weeks per os. Significant difference vs. control was found only in the weight of lung and popliteal lymph node (PLN). The Pb + Hg and Pb + Cd combinations significantly decreased the PLN to 100 g body weight and PLN to brain weight ratio, and Pb+Hg also decreased the relative adrenal weight. After 12 weeks treatment with the same doses, effects on the thymus, kidney, and adrenal weights in the Pb + Hg, and thymus weight in the Pb + Cd, combination were seen. Pb + Cd also affected the white and red blood cell count and hematocrit. Combined with Hg or Cd, NOEL dose Pb showed toxicity, indicating that exposure limits may be inefficient in combined exposure situations.

Original languageEnglish
Pages (from-to)433-439
Number of pages7
JournalActa Biologica Hungarica
Volume57
Issue number4
DOIs
Publication statusPublished - 2006

Fingerprint

Thymus
Rats
Weights and Measures
Cadmium Chloride
rats
lymph nodes
No-Observed-Adverse-Effect Level
no observed adverse effect level
dosage
Lymph Nodes
Toxicity
Brain
Acetates
Blood
Metals
Thymus Gland
Cells
Erythrocyte Count
erythrocyte count
Leukocyte Count

Keywords

  • Combination
  • Heavy metals
  • Hematology
  • Immunotoxicity
  • Rat

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Immunotoxicological investigation of subacute combined exposure with low doses of PB, HG and CD in rats. / Institóris, L.; Kovács, Dóra; Kecskeméti-Kovács, I.; Lukács, Anita; Szabó, A.; Lengyel, Zsuzsanna; Papp, A.; Nagymajtényi, L.; Dési, I.

In: Acta Biologica Hungarica, Vol. 57, No. 4, 2006, p. 433-439.

Research output: Contribution to journalArticle

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AU - Szabó, A.

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