Immunosuppressive effects of human placental trophoblast interferon-β on lymphocytes in vitro

M. Zdravkovic, G. Aboagye-Mathiesen, V. Zachar, F. Tóth, A. M. Dalsgard, H. Hager, P. Ebbesen

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Abstract

Human placental trophoblast cells produce predominantly interferon-beta-type (IFN-β) hen stimulated with viral inducers. The aim of the present study was to determine the in vitro antiproliferative effect of the trophoblast interferon-β (tro-IFN-β) on mitogen-stimulated and resting lymphocytes. The antiproliferative effect of the tro-IFN-β was compared to human recombinant IFN-β. All activities of tro-IFN-β and human recombinant IFN-β ranging between 10-1000IU/ml showed suppression of proliferative responses on mitogen-stimulated and resting lymphocytes compared to cultures without IFN treatment. The inhibitory level of both tro-IFN-β and recombinant IFN-β was significantly higher on the stimulated than on the resting lymphocytes. Although there was a variation in the inhibition of lymphocyte proliferation by both IFNs with respect to time, there was no statistically significant difference in the antiproliferative effect of the IFNs on both resting and mitogen stimulated lymphocytes. Since IFNs are produced locally by the placenta during pregnancy, our data suggest that in addition to the antiviral activity, the human tro-IFN-β may participate in the local control of the maternal immune response during pregnancy at the fetomaternal interface.

Original languageEnglish
Pages (from-to)591-600
Number of pages10
JournalPlacenta
Volume15
Issue number6
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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    Zdravkovic, M., Aboagye-Mathiesen, G., Zachar, V., Tóth, F., Dalsgard, A. M., Hager, H., & Ebbesen, P. (1994). Immunosuppressive effects of human placental trophoblast interferon-β on lymphocytes in vitro. Placenta, 15(6), 591-600.