Immunosuppressants increase the levels of natural autoantibodies reactive with glycosaminoglycans in myasthenia gravis

Zsuzsanna Pal, László Tóthfalusi, Zsolt Lörincz, Bence György, Maria Judit Molnar, Andras Falus, Edit I. Buzás

Research output: Contribution to journalArticle

Abstract

Increasing number of evidences support the role of glycosylation in the evolution of autoimmunity. We examined carbohydrate-reactive natural autoantibodies systematically for the first time in patients with autoimmune myasthenia gravis. Antibodies reactive to glycosaminoglycans were measured with CovaLink ELISA in the sera of 59 myasthenia patients as well as in 54 healthy controls. We used the GlycoChip carbohydrate array to characterize individual carbohydrate recognition patterns.Chondroitin-sulphate C and anti-α-mannose-specific IgG levels were significantly elevated in myasthenia patients. Unexpectedly, we found that immunosuppressants increased the levels of the protective IgM glycosaminoglycan-reactive natural antibodies demonstrating a new role for these agents in immunoregulation.

Original languageEnglish
Pages (from-to)224-228
Number of pages5
JournalJournal of Neuroimmunology
Volume276
Issue number1-2
DOIs
Publication statusPublished - Nov 15 2014

Keywords

  • Autoimmunity
  • Glycosylation
  • Muscle

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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