Immunoreceptor tyrosine-based inhibition motif-bearing receptors regulate the immunoreceptor tyrosine-based activation motif-induced activation of immune competent cells

J. Gergely, Israel Pecht, G. Sármay

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

ITIM-bearing receptors, a family which only recently has been recognized, play a key role in the regulation of the ITAM-induced activation of immune competent cells. The mechanism of ITM-mediated regulation in various cells was recently clarified. The present review focuses on ITIM bearing membrane proteins that negatively regulate the activation of cells when co-crosslinked with ITAM containing receptors, illustrates the inhibitory processes by the negative regulation of B-, NK-, T-cells and mast cells and summarizes current views on the mechanism of ITIM-mediated inhibition.

Original languageEnglish
Pages (from-to)3-15
Number of pages13
JournalImmunology Letters
Volume68
Issue number1
DOIs
Publication statusPublished - May 3 1999

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Immunoreceptor Tyrosine-Based Inhibition Motif
Immunoreceptor Tyrosine-Based Activation Motif
Mast Cells
Natural Killer Cells
Membrane Proteins
T-Lymphocytes

Keywords

  • Immune competent cells
  • ITAM
  • ITIM

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

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