Immunoreceptor-like signaling by β2 and β3 integrins

Z. Jakus, Szabina Fodor, Clare L. Abram, Clifford A. Lowell, A. Mócsai

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Although adhesion to extracellular structures is one of the most fundamental cell biological processes, the intracellular signals triggered by integrins, the most important receptors involved, are incompletely understood. Several recent reports indicate that signaling by β2 and β3 integrins in various cell types (neutrophils, macrophages, osteoclasts and platelets) use components of the signal transduction machinery of lymphocyte antigen receptors. Central to this immunoreceptor-like signaling is the phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters (such as DAP12 and the Fc receptor γ-chain) by Src-family kinases and the concomitant recruitment of the Syk tyrosine kinase through its dual SH2 domains. These and other reports reveal an unexpected similarity between the signal-transduction mechanisms used by integrins and immune recognition receptors.

Original languageEnglish
Pages (from-to)493-501
Number of pages9
JournalTrends in Cell Biology
Volume17
Issue number10
DOIs
Publication statusPublished - Oct 2007

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Integrins
Signal Transduction
Immunoreceptor Tyrosine-Based Activation Motif
Biological Phenomena
Antigen Receptors
src Homology Domains
src-Family Kinases
Fc Receptors
Osteoclasts
Protein-Tyrosine Kinases
Neutrophils
Blood Platelets
Macrophages
Phosphorylation
Lymphocytes
Syk Kinase

ASJC Scopus subject areas

  • Cell Biology

Cite this

Immunoreceptor-like signaling by β2 and β3 integrins. / Jakus, Z.; Fodor, Szabina; Abram, Clare L.; Lowell, Clifford A.; Mócsai, A.

In: Trends in Cell Biology, Vol. 17, No. 10, 10.2007, p. 493-501.

Research output: Contribution to journalArticle

Jakus, Z. ; Fodor, Szabina ; Abram, Clare L. ; Lowell, Clifford A. ; Mócsai, A. / Immunoreceptor-like signaling by β2 and β3 integrins. In: Trends in Cell Biology. 2007 ; Vol. 17, No. 10. pp. 493-501.
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