Immunoreactive dynorphin and α-neo-endorphin in rat hypothalamo-neurohypophyseal system

M. Palkóvits, Michael J. Brownstein, Nadav Zamir

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Concentrations of dynorphin and α-neo-endorphin were measured in rat supraoptic and paraventricular nuclei, median eminence and posterior pituitary. Paraventricular lesions did not alter the level of either peptide in the median eminence or posterior pituitary. Knife cuts in the lateral retrochiasmatic area that severed the supraoptico-hypophyseal tract reduced dynorphin and α-neo-endorphin levels by 64-80% in the posterior pituitary and by somewhat less in the median eminence. Knife cuts in the vicinity of the supraoptic nucleus that did not interrupt the supraoptico-hypophyseal tract did not affect peptide concentrations in the posterior pituitary. Our data suggest that dynorphin and α-neo-endorphin in the posterior pituitary are in processes of supraoptic nucleus neurons. These neurons also project to the median eminence which may receive fibers from other dynorphin and α-neo-endorphin containing cells too.

Original languageEnglish
Pages (from-to)258-261
Number of pages4
JournalBrain Research
Volume278
Issue number1-2
DOIs
Publication statusPublished - Nov 14 1983

Fingerprint

Endorphins
Dynorphins
Median Eminence
Supraoptic Nucleus
Neurons
Peptides
Paraventricular Hypothalamic Nucleus

Keywords

  • dynorphin
  • median eminence
  • paraventricular nucleus
  • posterior pituitary
  • supraoptic nucleus
  • α-neo-endorphin

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Immunoreactive dynorphin and α-neo-endorphin in rat hypothalamo-neurohypophyseal system. / Palkóvits, M.; Brownstein, Michael J.; Zamir, Nadav.

In: Brain Research, Vol. 278, No. 1-2, 14.11.1983, p. 258-261.

Research output: Contribution to journalArticle

Palkóvits, M. ; Brownstein, Michael J. ; Zamir, Nadav. / Immunoreactive dynorphin and α-neo-endorphin in rat hypothalamo-neurohypophyseal system. In: Brain Research. 1983 ; Vol. 278, No. 1-2. pp. 258-261.
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