Immunfenotípus vizsgálata akut leukaemiákban

a minimális reziduális betegség kimutatási lehetósége.

Translated title of the contribution: Immunophenotyping in acute leukemia: detection of minimal residual disease

K. Pálóczi, S. Nahajevszky, K. Jakab, N. Regéczy, L. Gopcsa, E. László, J. Földi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Immunophenotyping improves both accuracy and reproducibility of the acute leukaemia classification and is considered particularly useful for identifying poorly differentiated subtypes of acute myeloid leukaemia and lineage association of acute lymphoid leukaemia. Immunological studies of leukaemic blasts has become critical also identifying biphenotypic leukaemias and acute myeloid leukaemia expressing lymphoid associated markers. At present, while the prognostic value of individual antigen expressions is still controversial, the immunologic detection of minimal residual disease seems to be important in monitoring the acute leukaemia patients in remission. In the present study immunophenotyping of bone marrow samples of 42 patients with acute myeloid leukaemia and 13 patients with acute lymphoid leukaemia was analysed. Patients were assessed both before and after treatment by immunophenotyping, cytogenetics and polymerase chain reaction amplification. The immunophenotyping have allowed more sensitive definition of acute leukaemia relapse, but molecular genetic methods are recommended for detection of elimination of residual disease.

Original languageHungarian
Pages (from-to)2487-2492
Number of pages6
JournalOrvosi Hetilap
Volume141
Issue number46
Publication statusPublished - Nov 12 2000

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Immunophenotyping
Residual Neoplasm
Leukemia
Acute Myeloid Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Biphenotypic Acute Leukemia
Disease Eradication
Cytogenetics
Molecular Biology
Bone Marrow
Antigens
Recurrence
Polymerase Chain Reaction
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pálóczi, K., Nahajevszky, S., Jakab, K., Regéczy, N., Gopcsa, L., László, E., & Földi, J. (2000). Immunfenotípus vizsgálata akut leukaemiákban: a minimális reziduális betegség kimutatási lehetósége. Orvosi Hetilap, 141(46), 2487-2492.

Immunfenotípus vizsgálata akut leukaemiákban : a minimális reziduális betegség kimutatási lehetósége. / Pálóczi, K.; Nahajevszky, S.; Jakab, K.; Regéczy, N.; Gopcsa, L.; László, E.; Földi, J.

In: Orvosi Hetilap, Vol. 141, No. 46, 12.11.2000, p. 2487-2492.

Research output: Contribution to journalArticle

Pálóczi, K, Nahajevszky, S, Jakab, K, Regéczy, N, Gopcsa, L, László, E & Földi, J 2000, 'Immunfenotípus vizsgálata akut leukaemiákban: a minimális reziduális betegség kimutatási lehetósége.', Orvosi Hetilap, vol. 141, no. 46, pp. 2487-2492.
Pálóczi K, Nahajevszky S, Jakab K, Regéczy N, Gopcsa L, László E et al. Immunfenotípus vizsgálata akut leukaemiákban: a minimális reziduális betegség kimutatási lehetósége. Orvosi Hetilap. 2000 Nov 12;141(46):2487-2492.
Pálóczi, K. ; Nahajevszky, S. ; Jakab, K. ; Regéczy, N. ; Gopcsa, L. ; László, E. ; Földi, J. / Immunfenotípus vizsgálata akut leukaemiákban : a minimális reziduális betegség kimutatási lehetósége. In: Orvosi Hetilap. 2000 ; Vol. 141, No. 46. pp. 2487-2492.
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