The authors studied the effects of different radical scavengers (cyanidanol-3, dihydroquinoline type synthetic antioxidants, aicaphosphate, etc.) on the immune reaction. These drugs are used to treat chronic liver diseases or in experimental liver injury. The immunological effects were tested both in vitro by several methods of lymphocyte culture and in vivo in experimental animal models. Apart from its immunomodulatory effects, radical scavenger activity was also investigated by methods for lipid peroxidation. These drugs inhibit lipid peroxidation and have a membrane stabilizing effect. These effects were demonstrated on plasma membrane and on microsomal fractions of brain and liver, by the beta-glucuronidase activity of liver lysosomes in experimental animals and also by the release of beta-glucuronidase enzyme from the lysosomes. The immunomodulatory effects of the drugs vary. In some tests they exert immunostimulant and in others immunosuppressive effects. On the basis of the in vitro data the most appropriate drug can be selected for treatment of various chronic liver diseases. In chronic active hepatitis of autoimmune origin the immunosuppressive drugs can be recommended, and in hepatitis of viral origin the immunostimulant effect will be sought. In chemically-induced liver alterations the synthetic, non-toxic dihydroquinoline type antioxidants should be applied.
|Number of pages||14|
|Journal||Drugs under Experimental and Clinical Research|
|Publication status||Published - Jan 1 1984|
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery
- Pharmacology (medical)