Immunomodulatory effect of antidepressants

Judith Szelényi, Zsolt Selmeczy

Research output: Contribution to journalReview article

25 Citations (Scopus)


Basic and clinical studies have provided evidence that the biophase level of monoamines, determined by the balance of their release and uptake, is involved in the pathophysiology and treatment of depression, whereas other arguments cite the role of inflammatory mediators in the etiology of psychiatric disorders. A bidirectional interaction between the monoamine system and the inflammatory system might explain the concurrent therapeutical efficacy and immunomodulatory features of antidepressants.

Original languageEnglish
Pages (from-to)428-432
Number of pages5
JournalCurrent Opinion in Pharmacology
Issue number4
Publication statusPublished - Aug 1 2002


ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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