Makrolid antibiotikumok immunmodulátor és myelomaellenes hatásai

Translated title of the contribution: Immunomodulatory and anti-myeloma effects of macrolide antibiotics

Mikala Gábor, Jákó János, Vályi Nagy István

Research output: Contribution to journalArticle

Abstract

Systemic administration of macrolide antibiotics results in intracellular accumulation of the compounds that may modulate various cellular functions. The immunomodulatory effects may be significant among the non-antimicrobial activities and be of pronounced importance in certain disease states. Alteration of phospholipid metabolism as well as modulation of NF-κB activity participate in the immunomodulatory effects: secretion of proinflammatory cytokines is reduced. Clinically relevant immunomodulation is seen is several chronic inflammatory diseases, such as diffuse panbronchiolitis, bronchiectasy, chronic sinusitis and Crohn's disease. Macrolides - especially clarithromycin - possess pronounced anti-tumor effects, anti-angiogenesis may be pivotal among them. In the case of multiple myeloma, the effect of clarithromycin monotherapy is uncertain, however, the recently inroduced BLTD protocol (clarithromycin, low-dose thalidomide and dexamethason) is reported to be one of the most effective experimental regimes, even in post-transplant relapsing or therapy-resistant disease cases.

Original languageHungarian
Pages (from-to)241-249
Number of pages9
JournalOrvoskepzes
Volume77
Issue number4
Publication statusPublished - Dec 1 2002

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gábor, M., János, J., & István, V. N. (2002). Makrolid antibiotikumok immunmodulátor és myelomaellenes hatásai. Orvoskepzes, 77(4), 241-249.