Silymarin kezelés immunmoduláns hatása krónikus alkoholos májbetegségben.

Translated title of the contribution: Immunomodulator effect of silymarin therapy in chronic alcoholic liver diseases

G. Deák, G. Müzes, I. Láng, V. Niederland, K. Nékám, R. Gonzalez-Cabello, P. Gergely, J. Fehér

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The effects of the hepatoprotective, antioxidant drug silymarin (Legalon) on some cellular immune parameters of patients with histologically proven chronic alcoholic liver disease were studied in a six month double blind study. The lectin induced proliferative activity of the lymphocytes got enhanced, the originally low T cell percentage and the originally high CD8+ cell percentage have been normalized, the antibody-dependent and natural cytotoxicity of the lymphocytes decreased during silymarin therapy. All these changes were significant, while in the placebo group no significant changes occurred, except for a moderate elevation of the T cell percentage. Thus, the immunomodulatory activity of silymarin might be involved in the hepatoprotective action of the drug and improves the depressed immunoreactivity of the patients.

Original languageHungarian
Pages (from-to)1291-1292, 1295
JournalOrvosi Hetilap
Volume131
Issue number24
Publication statusPublished - Jun 17 1990

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Silymarin
Alcoholic Liver Diseases
Immunologic Factors
Lymphocytes
T-Lymphocytes
Therapeutics
Double-Blind Method
Lectins
Pharmaceutical Preparations
Antioxidants
Placebos
Antibodies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Silymarin kezelés immunmoduláns hatása krónikus alkoholos májbetegségben. / Deák, G.; Müzes, G.; Láng, I.; Niederland, V.; Nékám, K.; Gonzalez-Cabello, R.; Gergely, P.; Fehér, J.

In: Orvosi Hetilap, Vol. 131, No. 24, 17.06.1990, p. 1291-1292, 1295.

Research output: Contribution to journalArticle

Deák, G, Müzes, G, Láng, I, Niederland, V, Nékám, K, Gonzalez-Cabello, R, Gergely, P & Fehér, J 1990, 'Silymarin kezelés immunmoduláns hatása krónikus alkoholos májbetegségben.', Orvosi Hetilap, vol. 131, no. 24, pp. 1291-1292, 1295.
Deák G, Müzes G, Láng I, Niederland V, Nékám K, Gonzalez-Cabello R et al. Silymarin kezelés immunmoduláns hatása krónikus alkoholos májbetegségben. Orvosi Hetilap. 1990 Jun 17;131(24):1291-1292, 1295.
Deák, G. ; Müzes, G. ; Láng, I. ; Niederland, V. ; Nékám, K. ; Gonzalez-Cabello, R. ; Gergely, P. ; Fehér, J. / Silymarin kezelés immunmoduláns hatása krónikus alkoholos májbetegségben. In: Orvosi Hetilap. 1990 ; Vol. 131, No. 24. pp. 1291-1292, 1295.
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