Immunomodulation activity of phenothiazines, benzo[a]phenothiazines and benz[c]acridines

J. Molnar, Y. Mandi, I. Petri, S. Petofi, H. Sakagami, T. Kurihara, N. Motohashi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Some non-differentiation-induction benzo[a]phenothiazines and mutagenic benz[c]acridines more potently inhibited the mitogen-induced blast transformation of human-peripheral blood lmphocytes than differentiation-induction and non-mutagenic counterparts and phenothiazines. Differential absorption spectrophotometry revealed tight compex formation between these drugs and bacterial endotoxin or mitogens. All of these compounds only slightly affected antibody dependent cellular cytotoxicity and natural killer cell activity, but significantly inhibited the endotoxin-or heat-killed Staphylococcus aureus induced tumor necrosis factor production by human mononuclear cells. Pretreatment of mice with these drugs protected them from lethal E. coli infection. Quantumchemical analysis suggests a correlation between the biological activity of these compounds and some molecular orbital parameters such as the charge at C7, and the ratio of polar/total surface areas.

Original languageEnglish
Pages (from-to)439-442
Number of pages4
JournalAnticancer research
Volume13
Issue number2
Publication statusPublished - Jan 1 1993

Keywords

  • Benz[c]acridines
  • Benzo[a]phenothiazines
  • Molecular orbital
  • Phenothiazines

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Molnar, J., Mandi, Y., Petri, I., Petofi, S., Sakagami, H., Kurihara, T., & Motohashi, N. (1993). Immunomodulation activity of phenothiazines, benzo[a]phenothiazines and benz[c]acridines. Anticancer research, 13(2), 439-442.