Immunomodulating effect of acridine tautomers on eukaryotic cells.

I. B. Petri, I. Berek, A. M. Galy, J. Barbe, L. Berek, J. Molnár

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Abstract

The immunomodulating effect of some new amino- and imino-acridine derivatives, were investigated on antibody dependent cellular cytotoxicity (ADCC) and induced-blast transformation of lymphocytes. In different concentrations (2.0 x 10(-6) M, 4.0 x 10(-8) M and 2.0 x 10(-5) M) the drugs produced a suppression of PHA and ConA induced cell proliferative response except in the case of 2b, 2d and 2g amino-acridines. The suppressive effects were dose dependent and exhibited a higher inhibitory level in the case of imino-acridines. Some drugs at low concentration exerted a little enhancing effect on ADCC reaction.

Original languageEnglish
Pages (from-to)203-208
Number of pages6
JournalActa microbiologica et immunologica Hungarica
Volume42
Issue number2
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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    Petri, I. B., Berek, I., Galy, A. M., Barbe, J., Berek, L., & Molnár, J. (1995). Immunomodulating effect of acridine tautomers on eukaryotic cells. Acta microbiologica et immunologica Hungarica, 42(2), 203-208.