Immunomodulating effect of 2,3,4,5-tetrahydro-1H-3-benzazepines (a new class of non-nucleoside inhibitors of reverse transcriptase)

Livia Berek, Ildiko B. Petri, Eva Varga, Joseph Molnár, Masami Kawase, Setsuo Saito, Noboru Motohashi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effects of newly synthesized, reverse transcriptase inhibitors, 3-benzazepines, for their effects on natural killer (NK) cell and blast transformation in human peripheral blood mononuclear cells were investigated. The most effective reverse transcriptase inhibitors were KF1, KF2 and KF3, which primarily suppressed immunological functions. Besides the inhibition of T cell proliferation, the benzazepines also show inhibitory effect on NK cell functions, in particularly, against large granular lymphocytes and monocytes. The B lymphocytes and Fc mediated killer functions were less inhibited. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalInternational Journal of Antimicrobial Agents
Volume14
Issue number3
DOIs
Publication statusPublished - Apr 1 2000

Keywords

  • 2,3,4,5-Tetrahydro-1H-3-benzazepines
  • Blast transformation
  • Immunomodulating effect
  • NK reaction
  • Reverse transcriptase

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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