Immunomodulating activities on cellular cytotoxicity and the blast transformation of human lymphocytes by 10-[n-(phthalimido)alkyl-2-substituted-10H-phenothiazines and 1-(2-chloroethyl)-3-(2-substituted-10H-phenothiazin-10-yl)alkyl-1-ureas

Ilidikó B. Petri, Éva Szekeres, Éva Varga, Imre Berek, Joseph Molnár, Livia Berek, Masami Kawase, Noboru Motohashi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Phenothiazines, 10-[n-(phthalimido)alkyl-2-substituted-10H-phenothiazines, and 1-(2-chloroethyl)-3-(2-substituted-10H-phenothiazin-10-yl)alkyl-1- ureas were investigated for their effects on antibody-dependent cellular cytotoxicity (ADCC), natural killer (NK) cells and the blast transformation of human peripheral blood mononuclear cells. All of the compounds dose-dependently suppressed mitogen-stimulated T cell proliferation. In contrast, a strong enhancing effect on NK cell activity was detected mostly in the case of 1-(2-chloroethyl)-3-(2-substituted-10H-phenothiazin-10-yl)alkyl-1- ureas and their related compounds. The stimulating effect directly influenced the NK cells and was demonstrated at all tested concentrations.

Original languageEnglish
Pages (from-to)1247-1250
Number of pages4
JournalAnticancer research
Volume16
Issue number3 A
Publication statusPublished - May 1 1996

Keywords

  • 1-(2-chloroethyl)-3-(2-substituted-10H-phenothiazin-10-yl)alkyl-1- ureas
  • ADCC
  • Blast transformation
  • NK cell

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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