Immunology of uterine transplantation

A review

Srdjan Saso, Sadaf Ghaem-Maghami, Jayanta Chatterjee, Nancy Brewig, L. Ungár, J. Richard Smith, Giuseppe Del Priore

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The idea of using organ transplantation to solve quality-of-life issues was first introduced a century ago, with cornea transplants and thrusted before the world again in 1998, following a controversial hand transplant. Uterus transplantation (UTn) has been proposed as another quality-of-life transplant for the cure of permanent uterine factor infertility. In order to proceed in humans, a greater appreciation of the immunological mechanisms that underlie UTn is desirable. Allogeneic UTn (animal model) was first described by 2 studies in 1969. The first and only human UTn, performed in 2000, was an early attempt with limited use of animal model experiments prior to moving onto the human setting. Since then, work using rat, mouse, ovine, goat, and nonhuman primate models has demonstrated that the uterus is a very different but manageable organ immunologically compared to other transplanted organs. Therefore, specifically exploring immunological issues relating to UTn is a valuable and necessary part of the inevitable scientific process leading to successful human UTn.

Original languageEnglish
Pages (from-to)123-134
Number of pages12
JournalReproductive Sciences
Volume19
Issue number2
DOIs
Publication statusPublished - Feb 2012

Fingerprint

Transplantation Immunology
Uterus
Transplantation
Transplants
Animal Models
Quality of Life
Homologous Transplantation
Organ Transplantation
Goats
Cornea
Infertility
Primates
Sheep
Hand

Keywords

  • fertility
  • immunology
  • solid-organ transplantation
  • uterus

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Saso, S., Ghaem-Maghami, S., Chatterjee, J., Brewig, N., Ungár, L., Smith, J. R., & Priore, G. D. (2012). Immunology of uterine transplantation: A review. Reproductive Sciences, 19(2), 123-134. https://doi.org/10.1177/1933719111417887

Immunology of uterine transplantation : A review. / Saso, Srdjan; Ghaem-Maghami, Sadaf; Chatterjee, Jayanta; Brewig, Nancy; Ungár, L.; Smith, J. Richard; Priore, Giuseppe Del.

In: Reproductive Sciences, Vol. 19, No. 2, 02.2012, p. 123-134.

Research output: Contribution to journalArticle

Saso, S, Ghaem-Maghami, S, Chatterjee, J, Brewig, N, Ungár, L, Smith, JR & Priore, GD 2012, 'Immunology of uterine transplantation: A review', Reproductive Sciences, vol. 19, no. 2, pp. 123-134. https://doi.org/10.1177/1933719111417887
Saso S, Ghaem-Maghami S, Chatterjee J, Brewig N, Ungár L, Smith JR et al. Immunology of uterine transplantation: A review. Reproductive Sciences. 2012 Feb;19(2):123-134. https://doi.org/10.1177/1933719111417887
Saso, Srdjan ; Ghaem-Maghami, Sadaf ; Chatterjee, Jayanta ; Brewig, Nancy ; Ungár, L. ; Smith, J. Richard ; Priore, Giuseppe Del. / Immunology of uterine transplantation : A review. In: Reproductive Sciences. 2012 ; Vol. 19, No. 2. pp. 123-134.
@article{054a0baf4dc0443d841324f769134003,
title = "Immunology of uterine transplantation: A review",
abstract = "The idea of using organ transplantation to solve quality-of-life issues was first introduced a century ago, with cornea transplants and thrusted before the world again in 1998, following a controversial hand transplant. Uterus transplantation (UTn) has been proposed as another quality-of-life transplant for the cure of permanent uterine factor infertility. In order to proceed in humans, a greater appreciation of the immunological mechanisms that underlie UTn is desirable. Allogeneic UTn (animal model) was first described by 2 studies in 1969. The first and only human UTn, performed in 2000, was an early attempt with limited use of animal model experiments prior to moving onto the human setting. Since then, work using rat, mouse, ovine, goat, and nonhuman primate models has demonstrated that the uterus is a very different but manageable organ immunologically compared to other transplanted organs. Therefore, specifically exploring immunological issues relating to UTn is a valuable and necessary part of the inevitable scientific process leading to successful human UTn.",
keywords = "fertility, immunology, solid-organ transplantation, uterus",
author = "Srdjan Saso and Sadaf Ghaem-Maghami and Jayanta Chatterjee and Nancy Brewig and L. Ung{\'a}r and Smith, {J. Richard} and Priore, {Giuseppe Del}",
year = "2012",
month = "2",
doi = "10.1177/1933719111417887",
language = "English",
volume = "19",
pages = "123--134",
journal = "Reproductive Sciences",
issn = "1933-7191",
publisher = "SAGE Publications Inc.",
number = "2",

}

TY - JOUR

T1 - Immunology of uterine transplantation

T2 - A review

AU - Saso, Srdjan

AU - Ghaem-Maghami, Sadaf

AU - Chatterjee, Jayanta

AU - Brewig, Nancy

AU - Ungár, L.

AU - Smith, J. Richard

AU - Priore, Giuseppe Del

PY - 2012/2

Y1 - 2012/2

N2 - The idea of using organ transplantation to solve quality-of-life issues was first introduced a century ago, with cornea transplants and thrusted before the world again in 1998, following a controversial hand transplant. Uterus transplantation (UTn) has been proposed as another quality-of-life transplant for the cure of permanent uterine factor infertility. In order to proceed in humans, a greater appreciation of the immunological mechanisms that underlie UTn is desirable. Allogeneic UTn (animal model) was first described by 2 studies in 1969. The first and only human UTn, performed in 2000, was an early attempt with limited use of animal model experiments prior to moving onto the human setting. Since then, work using rat, mouse, ovine, goat, and nonhuman primate models has demonstrated that the uterus is a very different but manageable organ immunologically compared to other transplanted organs. Therefore, specifically exploring immunological issues relating to UTn is a valuable and necessary part of the inevitable scientific process leading to successful human UTn.

AB - The idea of using organ transplantation to solve quality-of-life issues was first introduced a century ago, with cornea transplants and thrusted before the world again in 1998, following a controversial hand transplant. Uterus transplantation (UTn) has been proposed as another quality-of-life transplant for the cure of permanent uterine factor infertility. In order to proceed in humans, a greater appreciation of the immunological mechanisms that underlie UTn is desirable. Allogeneic UTn (animal model) was first described by 2 studies in 1969. The first and only human UTn, performed in 2000, was an early attempt with limited use of animal model experiments prior to moving onto the human setting. Since then, work using rat, mouse, ovine, goat, and nonhuman primate models has demonstrated that the uterus is a very different but manageable organ immunologically compared to other transplanted organs. Therefore, specifically exploring immunological issues relating to UTn is a valuable and necessary part of the inevitable scientific process leading to successful human UTn.

KW - fertility

KW - immunology

KW - solid-organ transplantation

KW - uterus

UR - http://www.scopus.com/inward/record.url?scp=84859916625&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859916625&partnerID=8YFLogxK

U2 - 10.1177/1933719111417887

DO - 10.1177/1933719111417887

M3 - Article

VL - 19

SP - 123

EP - 134

JO - Reproductive Sciences

JF - Reproductive Sciences

SN - 1933-7191

IS - 2

ER -