A gesztációs trofoblaszt betegségek immunológiája I.

Translated title of the contribution: Immunology of the gestational trophoblastic diseases I

Zoltán Nagymányoki, Michael J. Callahan, Mana M. Parast, Ross S. Berkowitz, Samuel C. Mok, V. Fülöp

Research output: Contribution to journalArticle

Abstract

Cytotoxic T cells (Tc) and natural killer (NK) cells may play a role in controlling trophoblast invasion. This study was undertaken to determine the level of infiltration and antigen profile of immune cells and explore their relationship in normal placenta (NP) and molar tissues to understand better the biology of gestational trophoblastic diseases. Immunolocalization of CD8, Granzyme B (GrB), and FoxP3 was performed on sections prepared from 11 gestational age-matched NP, 19 partial moles (PM), and 18 complete moles (CM) to characterize effector (GrB+CD8+) and GrB- (GrB-CD8+) Tc cells, GrB+ NK cells (GrB+CD8-), and Treg (FoxP3+) cells. Immune cells infiltrated into the implantation site of normal placenta, PM, and CM with increasing frequency. Effector and GrB- Tc, GrB+ NK and Treg infiltration in the CM were significantly stronger than seen in the normal placenta (p=0.002, p=0.007, p=0.002, respectively). Immune cell infiltration was not detected in the villi or trophoblast of gestational tissues. Treg infiltration at the implantation site was only observed in PM and CM. In CM and PM Tc infiltration positively correlated with Treg infiltration (p=0.035), but Treg infiltration did not correlate with the Tc effector ratio (effector Tc cells / all Tc cells). In CM the cellular immune response at the implantation site was significantly more vigorous than seen in case of the normal placenta. These observations demonstrate that at the implantation site of CM, the number of effector Tc and GrB+ NK cells are increased and Treg cells may negatively regulate T lymphocyte activation.

Original languageHungarian
Pages (from-to)215-223
Number of pages9
JournalMagyar Noorvosok Lapja
Volume71
Issue number5
Publication statusPublished - 2008

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Gestational Trophoblastic Disease
Granzymes
Allergy and Immunology
T-Lymphocytes
Placenta
Natural Killer Cells
Trophoblasts
Regulatory T-Lymphocytes
Lymphocyte Activation
Cellular Immunity
Gestational Age
Antigens

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Nagymányoki, Z., Callahan, M. J., Parast, M. M., Berkowitz, R. S., Mok, S. C., & Fülöp, V. (2008). A gesztációs trofoblaszt betegségek immunológiája I. Magyar Noorvosok Lapja, 71(5), 215-223.

A gesztációs trofoblaszt betegségek immunológiája I. / Nagymányoki, Zoltán; Callahan, Michael J.; Parast, Mana M.; Berkowitz, Ross S.; Mok, Samuel C.; Fülöp, V.

In: Magyar Noorvosok Lapja, Vol. 71, No. 5, 2008, p. 215-223.

Research output: Contribution to journalArticle

Nagymányoki, Z, Callahan, MJ, Parast, MM, Berkowitz, RS, Mok, SC & Fülöp, V 2008, 'A gesztációs trofoblaszt betegségek immunológiája I.', Magyar Noorvosok Lapja, vol. 71, no. 5, pp. 215-223.
Nagymányoki Z, Callahan MJ, Parast MM, Berkowitz RS, Mok SC, Fülöp V. A gesztációs trofoblaszt betegségek immunológiája I. Magyar Noorvosok Lapja. 2008;71(5):215-223.
Nagymányoki, Zoltán ; Callahan, Michael J. ; Parast, Mana M. ; Berkowitz, Ross S. ; Mok, Samuel C. ; Fülöp, V. / A gesztációs trofoblaszt betegségek immunológiája I. In: Magyar Noorvosok Lapja. 2008 ; Vol. 71, No. 5. pp. 215-223.
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