Immunology of inflammatory bowel diseases

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The pathogenesis of inflammatory diseases involves complex interactions among genetic, environmental and immunologic factors, where the immune system plays a crucial role. The initiating factor may be a commonly present environmental antigen, but the defective mucosal immune response can't downregulate the inflammatory process, the resulting in chronic inflammation and tissue damage. The abnormal amplification of the immune system seems more likely to be a secondary and not a primary factor in the disease. IBD patients exhibit abnormalities in epithelial antigen presentation, and in the cellular and humoral immune system. The role of autoimmunity is unclear in IBD. The inflammatory mediator production and balance is also altered in IBD. Crohn's disease is characterised by a Th1 cytokine profile, while ulcerative colitis is characterised rather by a Th2 cytokine profile. Recent advances in the understanding of the pathogenesis of IBD led to major changes in the treatment of the disease. The newer agents target the key mediators involved in the inflammatory process.

Original languageEnglish
Pages (from-to)355-372
Number of pages18
JournalActa Physiologica Hungarica
Volume87
Issue number4
Publication statusPublished - 2000

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Allergy and Immunology
Inflammatory Bowel Diseases
Immune System
Cytokines
Mucosal Immunity
Antigen Presentation
Immunologic Factors
Autoimmunity
Ulcerative Colitis
Crohn Disease
Down-Regulation
Inflammation
Antigens
Therapeutics

Keywords

  • Chronic inflammation
  • Environmental antigen
  • Epithelial antigen presentation
  • Immunology
  • Inflammatory bowel diseases
  • Inflammatory process
  • Mucosal immune response
  • Th2 cytokine profile
  • Tissue damage

ASJC Scopus subject areas

  • Physiology

Cite this

Immunology of inflammatory bowel diseases. / Lakatos, L.

In: Acta Physiologica Hungarica, Vol. 87, No. 4, 2000, p. 355-372.

Research output: Contribution to journalArticle

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