A hepatitis C-vírus-infekció immunológiája: Az elégtelen celluláris immunválasz okai és az antivirális kezelés hatásai

Translated title of the contribution: Immunology of HCV infection: The causes of impaired cellular immune response and the effect of antiviral treatment

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: The outcome of HCV infection and the response to antiviral treatment depend on both viral and host factors. Host immune response contributes not only to viral control, clinical recovery and protective immunity, but also to chronic hepatitis and liver cirrhosis. Establishing immunological status and identifying pretreatment immunological factors associated with better response to therapy might be of importance in the understanding of the successful immune response and in the future of combination therapy to HCV infection. Aims: The authors delivered a review on the immunology of HCV infection and characterized the cause of impaired cellular immune response in chronic HCV infection Natural killer (NK) cell activity, perforin and the inhibitory CD81 HCV co-receptor expression, and Th1/Th2 cytokine production of the monocytes and lymphocytes have been investigated. Patients and methods: 42 patients with chronic hepatitis C, out of them 25 being on interferon (PEG-IFN) + ribavirin (RBV) therapy, 12 sustained virological responders, 26 HCV carriers with normal transaminase values and 22 healthy controls were studied. NK cell activity, perforin and CD81 expression, the IFNγ, TNFα, IL-2 (Th1) and IL-4, IL-6, IL-10 (Th2) production of LPS stimulated monocytes and PMA + ionomycine stimulated lymphocytes were measured by flow-cytometry. Results: In patients with chronic hepatitis C we demonstrated decreased NK cell activity associated with increased CD81 expression. The perforin expression of lymphocytes was also impaired in HCV patients. The pretreatment capacity of the macrophages to produce TNFα was predictive for sustained virological response. This increased TNFα production of the monocytes counteracted the observed impaired Th1 type cytokine production of the lymphocytes. IL-10 and IL-4 production showed positive correlation with HCV RNA levels, and negative correlation with histological activity index was noted. PEG-IFN + RBV treatment increased NK activity, perforin expression, Th1 type cytokine production of the lymphocytes and downregulated CD81 expression inducing effective cellular immune response against HCV. The authors' results provide further data to understand the causes of impaired cellular immune response in chronic HCV hepatitis and may be useful in the developement of immuntherapy as an adjunctive treatment to cure patients with chronic hepatitis C.

Original languageHungarian
Pages (from-to)591-600
Number of pages10
JournalOrvosi Hetilap
Volume147
Issue number13
Publication statusPublished - Apr 2 2006

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Allergy and Immunology
Cellular Immunity
Antiviral Agents
Perforin
Lymphocytes
Chronic Hepatitis C
Infection
Natural Killer Cells
Monocytes
Ribavirin
Chronic Hepatitis
Cytokines
Interleukin-4
Interleukin-10
Therapeutics
Immunologic Factors
Transaminases
Liver Cirrhosis
Interferons
Interleukin-2

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{4dd00e3b71b442f7b522b52ca6c7e1af,
title = "A hepatitis C-v{\'i}rus-infekci{\'o} immunol{\'o}gi{\'a}ja: Az el{\'e}gtelen cellul{\'a}ris immunv{\'a}lasz okai {\'e}s az antivir{\'a}lis kezel{\'e}s hat{\'a}sai",
abstract = "Background: The outcome of HCV infection and the response to antiviral treatment depend on both viral and host factors. Host immune response contributes not only to viral control, clinical recovery and protective immunity, but also to chronic hepatitis and liver cirrhosis. Establishing immunological status and identifying pretreatment immunological factors associated with better response to therapy might be of importance in the understanding of the successful immune response and in the future of combination therapy to HCV infection. Aims: The authors delivered a review on the immunology of HCV infection and characterized the cause of impaired cellular immune response in chronic HCV infection Natural killer (NK) cell activity, perforin and the inhibitory CD81 HCV co-receptor expression, and Th1/Th2 cytokine production of the monocytes and lymphocytes have been investigated. Patients and methods: 42 patients with chronic hepatitis C, out of them 25 being on interferon (PEG-IFN) + ribavirin (RBV) therapy, 12 sustained virological responders, 26 HCV carriers with normal transaminase values and 22 healthy controls were studied. NK cell activity, perforin and CD81 expression, the IFNγ, TNFα, IL-2 (Th1) and IL-4, IL-6, IL-10 (Th2) production of LPS stimulated monocytes and PMA + ionomycine stimulated lymphocytes were measured by flow-cytometry. Results: In patients with chronic hepatitis C we demonstrated decreased NK cell activity associated with increased CD81 expression. The perforin expression of lymphocytes was also impaired in HCV patients. The pretreatment capacity of the macrophages to produce TNFα was predictive for sustained virological response. This increased TNFα production of the monocytes counteracted the observed impaired Th1 type cytokine production of the lymphocytes. IL-10 and IL-4 production showed positive correlation with HCV RNA levels, and negative correlation with histological activity index was noted. PEG-IFN + RBV treatment increased NK activity, perforin expression, Th1 type cytokine production of the lymphocytes and downregulated CD81 expression inducing effective cellular immune response against HCV. The authors' results provide further data to understand the causes of impaired cellular immune response in chronic HCV hepatitis and may be useful in the developement of immuntherapy as an adjunctive treatment to cure patients with chronic hepatitis C.",
keywords = "CD81 expression, HCV, IFN, Immunology, Natural killer cell, Perforin, Th1/Th2 cytokines, TNFα",
author = "G. P{\'a}r and T. Berki and L. P{\'a}link{\'a}s and P. Balogh and L. Szereday and Melinda Hal{\'a}sz and J. Szekeres-Barth{\'o} and A. Miseta and G{\'e}za Hegedus and G. M{\'o}zsik and B. Hunyady and A. P{\'a}r",
year = "2006",
month = "4",
day = "2",
language = "Hungarian",
volume = "147",
pages = "591--600",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "13",

}

TY - JOUR

T1 - A hepatitis C-vírus-infekció immunológiája

T2 - Az elégtelen celluláris immunválasz okai és az antivirális kezelés hatásai

AU - Pár, G.

AU - Berki, T.

AU - Pálinkás, L.

AU - Balogh, P.

AU - Szereday, L.

AU - Halász, Melinda

AU - Szekeres-Barthó, J.

AU - Miseta, A.

AU - Hegedus, Géza

AU - Mózsik, G.

AU - Hunyady, B.

AU - Pár, A.

PY - 2006/4/2

Y1 - 2006/4/2

N2 - Background: The outcome of HCV infection and the response to antiviral treatment depend on both viral and host factors. Host immune response contributes not only to viral control, clinical recovery and protective immunity, but also to chronic hepatitis and liver cirrhosis. Establishing immunological status and identifying pretreatment immunological factors associated with better response to therapy might be of importance in the understanding of the successful immune response and in the future of combination therapy to HCV infection. Aims: The authors delivered a review on the immunology of HCV infection and characterized the cause of impaired cellular immune response in chronic HCV infection Natural killer (NK) cell activity, perforin and the inhibitory CD81 HCV co-receptor expression, and Th1/Th2 cytokine production of the monocytes and lymphocytes have been investigated. Patients and methods: 42 patients with chronic hepatitis C, out of them 25 being on interferon (PEG-IFN) + ribavirin (RBV) therapy, 12 sustained virological responders, 26 HCV carriers with normal transaminase values and 22 healthy controls were studied. NK cell activity, perforin and CD81 expression, the IFNγ, TNFα, IL-2 (Th1) and IL-4, IL-6, IL-10 (Th2) production of LPS stimulated monocytes and PMA + ionomycine stimulated lymphocytes were measured by flow-cytometry. Results: In patients with chronic hepatitis C we demonstrated decreased NK cell activity associated with increased CD81 expression. The perforin expression of lymphocytes was also impaired in HCV patients. The pretreatment capacity of the macrophages to produce TNFα was predictive for sustained virological response. This increased TNFα production of the monocytes counteracted the observed impaired Th1 type cytokine production of the lymphocytes. IL-10 and IL-4 production showed positive correlation with HCV RNA levels, and negative correlation with histological activity index was noted. PEG-IFN + RBV treatment increased NK activity, perforin expression, Th1 type cytokine production of the lymphocytes and downregulated CD81 expression inducing effective cellular immune response against HCV. The authors' results provide further data to understand the causes of impaired cellular immune response in chronic HCV hepatitis and may be useful in the developement of immuntherapy as an adjunctive treatment to cure patients with chronic hepatitis C.

AB - Background: The outcome of HCV infection and the response to antiviral treatment depend on both viral and host factors. Host immune response contributes not only to viral control, clinical recovery and protective immunity, but also to chronic hepatitis and liver cirrhosis. Establishing immunological status and identifying pretreatment immunological factors associated with better response to therapy might be of importance in the understanding of the successful immune response and in the future of combination therapy to HCV infection. Aims: The authors delivered a review on the immunology of HCV infection and characterized the cause of impaired cellular immune response in chronic HCV infection Natural killer (NK) cell activity, perforin and the inhibitory CD81 HCV co-receptor expression, and Th1/Th2 cytokine production of the monocytes and lymphocytes have been investigated. Patients and methods: 42 patients with chronic hepatitis C, out of them 25 being on interferon (PEG-IFN) + ribavirin (RBV) therapy, 12 sustained virological responders, 26 HCV carriers with normal transaminase values and 22 healthy controls were studied. NK cell activity, perforin and CD81 expression, the IFNγ, TNFα, IL-2 (Th1) and IL-4, IL-6, IL-10 (Th2) production of LPS stimulated monocytes and PMA + ionomycine stimulated lymphocytes were measured by flow-cytometry. Results: In patients with chronic hepatitis C we demonstrated decreased NK cell activity associated with increased CD81 expression. The perforin expression of lymphocytes was also impaired in HCV patients. The pretreatment capacity of the macrophages to produce TNFα was predictive for sustained virological response. This increased TNFα production of the monocytes counteracted the observed impaired Th1 type cytokine production of the lymphocytes. IL-10 and IL-4 production showed positive correlation with HCV RNA levels, and negative correlation with histological activity index was noted. PEG-IFN + RBV treatment increased NK activity, perforin expression, Th1 type cytokine production of the lymphocytes and downregulated CD81 expression inducing effective cellular immune response against HCV. The authors' results provide further data to understand the causes of impaired cellular immune response in chronic HCV hepatitis and may be useful in the developement of immuntherapy as an adjunctive treatment to cure patients with chronic hepatitis C.

KW - CD81 expression

KW - HCV

KW - IFN

KW - Immunology

KW - Natural killer cell

KW - Perforin

KW - Th1/Th2 cytokines

KW - TNFα

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M3 - Article

C2 - 16623441

AN - SCOPUS:33646944184

VL - 147

SP - 591

EP - 600

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

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