Immunologically induced peliosis hepatis in rats

E. Husztik, G. Lazar, E. Szabo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Peliosis hepatis has been induced immunologically with anti-rat glomerular basal membrane rabbit serum in rat pre-sensitized with a rare earth metal complex, neodymium pyrocatechin disulphonate (NPD). This is the first experimental evidence that peliosis hepatis may develop as a result of an immunological process. It is noteworthy that in this experimental form of peliosis hepatis and in that observed earlier in rats treated with basic polyglutamic acid derivatives, severe defibrination was detected and, as in most human cases, not only the liver but other organs were also involved in the peliotic lesions. Since the rare earth metal compounds, among them the pyrocatechin disulphonate complex of neodymium, depress the reticulo-endothelial activity, a role of the reticulo-endothelial system in the pathogenesis of this experimental form of peliosis hepatis is suggested.

Original languageEnglish
Pages (from-to)313-318
Number of pages6
JournalBritish Journal of Experimental Pathology
Volume65
Issue number3
Publication statusPublished - 1984

Fingerprint

Peliosis Hepatis
Rare Earth Metals
Polyglutamic Acid
Coordination Complexes
Rabbits
Membranes
Liver
Serum

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Immunologically induced peliosis hepatis in rats. / Husztik, E.; Lazar, G.; Szabo, E.

In: British Journal of Experimental Pathology, Vol. 65, No. 3, 1984, p. 313-318.

Research output: Contribution to journalArticle

Husztik, E. ; Lazar, G. ; Szabo, E. / Immunologically induced peliosis hepatis in rats. In: British Journal of Experimental Pathology. 1984 ; Vol. 65, No. 3. pp. 313-318.
@article{54bc09ebc4154c12984952f43ed59863,
title = "Immunologically induced peliosis hepatis in rats",
abstract = "Peliosis hepatis has been induced immunologically with anti-rat glomerular basal membrane rabbit serum in rat pre-sensitized with a rare earth metal complex, neodymium pyrocatechin disulphonate (NPD). This is the first experimental evidence that peliosis hepatis may develop as a result of an immunological process. It is noteworthy that in this experimental form of peliosis hepatis and in that observed earlier in rats treated with basic polyglutamic acid derivatives, severe defibrination was detected and, as in most human cases, not only the liver but other organs were also involved in the peliotic lesions. Since the rare earth metal compounds, among them the pyrocatechin disulphonate complex of neodymium, depress the reticulo-endothelial activity, a role of the reticulo-endothelial system in the pathogenesis of this experimental form of peliosis hepatis is suggested.",
author = "E. Husztik and G. Lazar and E. Szabo",
year = "1984",
language = "English",
volume = "65",
pages = "313--318",
journal = "International Journal of Experimental Pathology",
issn = "0959-9673",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Immunologically induced peliosis hepatis in rats

AU - Husztik, E.

AU - Lazar, G.

AU - Szabo, E.

PY - 1984

Y1 - 1984

N2 - Peliosis hepatis has been induced immunologically with anti-rat glomerular basal membrane rabbit serum in rat pre-sensitized with a rare earth metal complex, neodymium pyrocatechin disulphonate (NPD). This is the first experimental evidence that peliosis hepatis may develop as a result of an immunological process. It is noteworthy that in this experimental form of peliosis hepatis and in that observed earlier in rats treated with basic polyglutamic acid derivatives, severe defibrination was detected and, as in most human cases, not only the liver but other organs were also involved in the peliotic lesions. Since the rare earth metal compounds, among them the pyrocatechin disulphonate complex of neodymium, depress the reticulo-endothelial activity, a role of the reticulo-endothelial system in the pathogenesis of this experimental form of peliosis hepatis is suggested.

AB - Peliosis hepatis has been induced immunologically with anti-rat glomerular basal membrane rabbit serum in rat pre-sensitized with a rare earth metal complex, neodymium pyrocatechin disulphonate (NPD). This is the first experimental evidence that peliosis hepatis may develop as a result of an immunological process. It is noteworthy that in this experimental form of peliosis hepatis and in that observed earlier in rats treated with basic polyglutamic acid derivatives, severe defibrination was detected and, as in most human cases, not only the liver but other organs were also involved in the peliotic lesions. Since the rare earth metal compounds, among them the pyrocatechin disulphonate complex of neodymium, depress the reticulo-endothelial activity, a role of the reticulo-endothelial system in the pathogenesis of this experimental form of peliosis hepatis is suggested.

UR - http://www.scopus.com/inward/record.url?scp=0021242037&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021242037&partnerID=8YFLogxK

M3 - Article

C2 - 6547617

AN - SCOPUS:0021242037

VL - 65

SP - 313

EP - 318

JO - International Journal of Experimental Pathology

JF - International Journal of Experimental Pathology

SN - 0959-9673

IS - 3

ER -