MECANISMES IMMUNOLOGIQUES DU PSORIASIS

Translated title of the contribution: Immunological mechanisms in psoriasis

R. H. Cormane, J. Hunyadi, F. Hamerlinck

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)

Abstract

The occurrence of ANA in eluates of lymphocytes and polymorphonuclear leucocytes obtained in 5 untreated psoriasis patients could be dmonstrated by means of the indirect immunofluorescence technique. These antibodies appear to be mainly directed against the nuclei of the basal cell layer; however, ANA directed against the nuclei of epidermal and dermal cells have also been encountered. The immunological mechanism in psoriasis may therefore be looked upon as the result of an alteration in the structure of nucleic acid or nuclear protein of the basal layer cells. Finally psoriasis may be the result of an interplay of various exogenous factors and special genetical make-up leading to the release of certain nuclear proteins initiating a delayed type immune response at the onset an an Arthus type reaction located in the upper layers of the epidermis at a later stage of the disease, and as a secondary phenomenon the derailment of keratinization. Moreover a slightly decreased mean percentage of circulating lymphocytes forming rosettes with sheep erythrocytes have been found in the patients studied. This slight decrease suggests a diminution of the T-lymphocyte control facilitating the antibody production by B-lymphocytes. The course of events in psoriasis is a self perpetuating inflammatory process.

Original languageFrench
Title of host publicationAnnales de Dermatologie et de Syphiligraphie
Pages567-572
Number of pages6
Volume103
Edition5-6
Publication statusPublished - 1976

Fingerprint

Psoriasis
Nuclear Proteins
Arthus Reaction
Lymphocytes
Indirect Fluorescent Antibody Technique
Basal Ganglia
Cell Nucleus
Epidermis
Nucleic Acids
Antibody Formation
Sheep
Neutrophils
B-Lymphocytes
Erythrocytes
T-Lymphocytes
Skin
Antibodies

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)

Cite this

Cormane, R. H., Hunyadi, J., & Hamerlinck, F. (1976). MECANISMES IMMUNOLOGIQUES DU PSORIASIS. In Annales de Dermatologie et de Syphiligraphie (5-6 ed., Vol. 103, pp. 567-572)

MECANISMES IMMUNOLOGIQUES DU PSORIASIS. / Cormane, R. H.; Hunyadi, J.; Hamerlinck, F.

Annales de Dermatologie et de Syphiligraphie. Vol. 103 5-6. ed. 1976. p. 567-572.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cormane, RH, Hunyadi, J & Hamerlinck, F 1976, MECANISMES IMMUNOLOGIQUES DU PSORIASIS. in Annales de Dermatologie et de Syphiligraphie. 5-6 edn, vol. 103, pp. 567-572.
Cormane RH, Hunyadi J, Hamerlinck F. MECANISMES IMMUNOLOGIQUES DU PSORIASIS. In Annales de Dermatologie et de Syphiligraphie. 5-6 ed. Vol. 103. 1976. p. 567-572
Cormane, R. H. ; Hunyadi, J. ; Hamerlinck, F. / MECANISMES IMMUNOLOGIQUES DU PSORIASIS. Annales de Dermatologie et de Syphiligraphie. Vol. 103 5-6. ed. 1976. pp. 567-572
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