Immunological effects of photodynamic therapy in the treatment of actinic keratosis and squamous cell carcinoma

Emese Gellén, Eszter Fidrus, Margit Péter, Andrea Szegedi, Gabriella Emri, Éva Remenyik

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

The use of photodynamic therapy is extensive, due to its antitumoral, antibacterial and photorejuvenation effects. It destroys tumor via direct cell destruction and indirectly via vascular shutdown, induction of acute local inflammatory response and activation of the immune system. Both innate and adaptive immune cells are involved in the immunological effects of photodynamic therapy. In addition to UV-induced DNA damage, inflammation and immunosuppression are also essential elements in the pathogenesis of actinic keratosis. Both immunosuppression induced by UV and defective immune response to dysplastic keratinocytes may be the target of photodynamic therapy to eliminate actinic keratosis. These elements are discussed in the present review, highlighting the possible mechanism of photodynamic therapy to effectively treat actinic keratosis.

Original languageEnglish
Pages (from-to)342-348
Number of pages7
JournalPhotodiagnosis and Photodynamic Therapy
Volume24
DOIs
Publication statusPublished - Dec 2018

Keywords

  • Actinic keratosis
  • Immunology
  • Photodynamic therapy

ASJC Scopus subject areas

  • Biophysics
  • Oncology
  • Dermatology
  • Pharmacology (medical)

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