Immunological and molecular biological identification of a true case of T-hariy cell leukemia

J. Demeter, K. Pálóczi, J. Foldi, M. Hokland, P. Hokland, M. Benczur, D. Lehoczky

Research output: Contribution to journalArticle

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Abstract

A hairy cell leukaemia (HCL) patient is presented in whom the peripheral blood mononuclear cells (PBMCs) carried suppressor T-cell markers (CD3+, CD2+, CD8+/CD4-, CD38+). Analysis of genomic DNA of PBMNC showed the presence of a monoclonal population of T cells, the T-cell receptor (TCR) beta-chain gene being rearranged on both alleles (DR/DR), while the immunoglobulin (Ig) heavy chain-genes were in germline configuration. The neoplastic cells were found to react with the monoclonal antibody RAB-1 - originally described as belonging to the B lineage-restricted monoclonal antibodies - and to carry RAB-1/CD-8 in a double marker assay. Natural killer activity of PBMNCs against K562 target cells was severely reduced, while the cells were found to exert strong antibody-dependent cellular cytotoxicity.

Original languageEnglish
Pages (from-to)339-345
Number of pages7
JournalEuropean Journal of Haematology
Volume43
Issue number4
Publication statusPublished - 1989

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T-Cell Leukemia
Monoclonal Antibodies
T-Cell Receptor beta Genes
Immunoglobulin Heavy Chain Genes
T-Lymphocytes
Hairy Cell Leukemia
K562 Cells
Blood Cells
Alleles
Antibodies
DNA
Population

ASJC Scopus subject areas

  • Hematology

Cite this

Immunological and molecular biological identification of a true case of T-hariy cell leukemia. / Demeter, J.; Pálóczi, K.; Foldi, J.; Hokland, M.; Hokland, P.; Benczur, M.; Lehoczky, D.

In: European Journal of Haematology, Vol. 43, No. 4, 1989, p. 339-345.

Research output: Contribution to journalArticle

Demeter, J, Pálóczi, K, Foldi, J, Hokland, M, Hokland, P, Benczur, M & Lehoczky, D 1989, 'Immunological and molecular biological identification of a true case of T-hariy cell leukemia', European Journal of Haematology, vol. 43, no. 4, pp. 339-345.
Demeter, J. ; Pálóczi, K. ; Foldi, J. ; Hokland, M. ; Hokland, P. ; Benczur, M. ; Lehoczky, D. / Immunological and molecular biological identification of a true case of T-hariy cell leukemia. In: European Journal of Haematology. 1989 ; Vol. 43, No. 4. pp. 339-345.
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