Immunologic pathomechanism of Hodgkin's lymphoma

Adam Jona, Peter Szodoray, A. Illés

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Hodgkin's lymphoma is a lymphoid malignancy of the immune system. The pathognomonic Hodgkin and Reed-Sternberg cells (HRS) are derived mainly from monoclonal, preapoptotic B cells, and they carry rearranged, somatically mutated immunoglobulin heavy chains. In an appropriate microenvironment, HRS cells escape from apoptosis by several mechanisms, including single mutations, aberrant signaling pathways. Eventually, weakened immune surveillance leads to uncontrolled, disproportional B cell proliferation. This review summarizes the latest findings on the pathogenesis of Hodgkin lymphoma, with a special emphasis on immunologic processes, and depicts current and future immunotherapeutic regimens, which improve treatment outcomes and reduce late toxicities.

Original languageEnglish
Pages (from-to)995-1004
Number of pages10
JournalExperimental Hematology
Volume41
Issue number12
DOIs
Publication statusPublished - Dec 2013

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Hodgkin Disease
Reed-Sternberg Cells
B-Lymphocytes
Immunoglobulin Heavy Chains
Immune System
Cell Proliferation
Apoptosis
Mutation
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Hematology

Cite this

Immunologic pathomechanism of Hodgkin's lymphoma. / Jona, Adam; Szodoray, Peter; Illés, A.

In: Experimental Hematology, Vol. 41, No. 12, 12.2013, p. 995-1004.

Research output: Contribution to journalArticle

Jona, Adam ; Szodoray, Peter ; Illés, A. / Immunologic pathomechanism of Hodgkin's lymphoma. In: Experimental Hematology. 2013 ; Vol. 41, No. 12. pp. 995-1004.
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