Immunologic factors contributing to the initiation of labor-Lymphocyte reactivity in term labor and threatened preterm delivery

Julia Szekeres-Bartho, P. Varga, A. S. Pacsa

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

To obtain data on the immunologic events during labor, we investigated cytotoxic activity, progesterone-prostaglandin F and prostaglandin E2 sensitivity of the lymphocytes in late pregnancy at early and late stages of labor and in the puerperium. In an attempt to investigate common determinants between the behavior of lymphocytes during labor and threatened preterm delivery, the same parameters of lymphocytes obtained from women with threatened preterm delivery were tested in parallel. At the beginning of labor, cytotoxic activity of the lymphocytes significantly increased and remained at a high level till the end of labor. A negative correlation (r = -0.803) was found between the increase of cytotoxicity and the duration of labor. High progesterone sensitivity of pregnancy lymphocytes decreased while low sensitivity to prostaglandin E2 increased during labor. Sensitivity of the lymphocytes to prostaglandin F was similar in all of the groups examined. Except for prostaglandin E2 sensitivity all parameters of the lymphocytes obtained from women with threatened preterm delivery were similar to those of lymphocytes obtained during labor.

Original languageEnglish
Pages (from-to)108-112
Number of pages5
JournalAmerican journal of obstetrics and gynecology
Volume155
Issue number1
DOIs
Publication statusPublished - Jul 1986

Keywords

  • Cytotoxicity
  • progesterone
  • prostaglandin

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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