Immunohistochemical visualization of a metabotropic glutamate receptor

Tamás J. Göres, B. Penke, Zsuzsanna Böti, Zója Katarova, J. Hámori

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The immunocytochemical localization of the recently cloned metabotropic glutamate receptor lα (mGluRlα) was demonstrated with a C-terminus specific antibody in rat cerebellar cortex. This antibody detects a 138-140 kDa major, and a 46 kDa minor band in membrane preparations of rat cortex and cerebellum. mGluRlα immuno-reactivity (mGRi) was present in Purkinje and basket cells. Purkinje cell dendritic spines and their postsynaptic membranes showed selective labelling. Presynaptic membranes, parallel fibres and glial processes were devoid of mGRi. It is suggested that the selective postsynaptic localization of this receptor at the dendritic spines of Purkinje cells serves as the morphological basis for long term depression processes in the molecular layer of the cerebellar cortex.

Original languageEnglish
Pages (from-to)283-286
Number of pages4
JournalNeuroReport
Volume4
Issue number3
Publication statusPublished - 1993

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Metabotropic Glutamate Receptors
Purkinje Cells
Dendritic Spines
Cerebellar Cortex
Membranes
Antibodies
Neuroglia
Cerebellum

Keywords

  • Cerebellum
  • Immunocytochemistry
  • Long term depression
  • mGluRlα
  • Purkinje cell dendritic spine

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Immunohistochemical visualization of a metabotropic glutamate receptor. / Göres, Tamás J.; Penke, B.; Böti, Zsuzsanna; Katarova, Zója; Hámori, J.

In: NeuroReport, Vol. 4, No. 3, 1993, p. 283-286.

Research output: Contribution to journalArticle

Göres, TJ, Penke, B, Böti, Z, Katarova, Z & Hámori, J 1993, 'Immunohistochemical visualization of a metabotropic glutamate receptor', NeuroReport, vol. 4, no. 3, pp. 283-286.
Göres, Tamás J. ; Penke, B. ; Böti, Zsuzsanna ; Katarova, Zója ; Hámori, J. / Immunohistochemical visualization of a metabotropic glutamate receptor. In: NeuroReport. 1993 ; Vol. 4, No. 3. pp. 283-286.
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