Immunohistochemical studies using immunized guinea pig sera with features of anti-human thyroid, eye and skeletal antibody and graves' sera

Ildikó Molnár, Zita Szombathy, I. Kovács, A. József Szentmiklósi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Type 2 5′ deiodinase enzyme was observed in both thyroid and eye muscle tissues, highlighting its possible role as a common antigen in thyroid-associated ophthalmopathy. Sera of 105 Graves' patients and 40 controls, and immunized guinea pig sera against TCSS peptide, showing homology to the amino acid sequence from 132 to 152 of type 2 5′ deiodinase, were investigated to demonstrate the binding effects to human thyroid, eye and skeletal muscle tissues. Twenty-two Graves' patients were positive for anti-TCSS peptide antibodies, of whom 18 cases had ophthalmopathy. The levels of anti-TCSS peptide antibodies were higher not only in Graves' patients with (P

Original languageEnglish
Pages (from-to)172-180
Number of pages9
JournalJournal of Clinical Immunology
Volume27
Issue number2
DOIs
Publication statusPublished - Mar 2007

Fingerprint

Iodide Peroxidase
Thyroid Gland
Guinea Pigs
Peptides
Antibodies
Serum
Graves Ophthalmopathy
Amino Acid Sequence Homology
Muscles
Skeletal Muscle
Antigens
Enzymes

Keywords

  • Antibodies
  • Eye and skeletal muscle
  • Graves' ophthalmopathy
  • Thyroid
  • Type 2 5′ deiodinase

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Immunohistochemical studies using immunized guinea pig sera with features of anti-human thyroid, eye and skeletal antibody and graves' sera. / Molnár, Ildikó; Szombathy, Zita; Kovács, I.; Szentmiklósi, A. József.

In: Journal of Clinical Immunology, Vol. 27, No. 2, 03.2007, p. 172-180.

Research output: Contribution to journalArticle

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